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European Heart Journal Advance Access originally published online on July 3, 2006
European Heart Journal 2006 27(16):1895-1897; doi:10.1093/eurheartj/ehl130
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© The European Society of Cardiology 2006. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

The dilemma of left ventricular outflow tract obstruction and sudden death in hypertrophic cardiomyopathy: do patients with gradients really deserve prophylactic defibrillators?

Barry J. Maron1,*, Iacopo Olivotto2 and Martin S. Maron3

1 Hypertrophic Cardiomyopathy Center, Minneapolis Heart Institute Foundation, 920 E. 28th Street, Suite 60, Minneapolis, MN 55407, USA
2 Department of Cardiology, Referral Center for Myocardial Diseases, Azienda Ospedaliera Universitaria Careggi, Florence, Italy
3 Department of Cardiology, Hypertrophic Cardiomyopathy Center, Tufts-New England Medical Center, Boston, MA, USA

* * Corresponding author. Tel: +1 612 863 3996; fax: +1 612 863 3875. E-mail address: hcm.maron@mhif.org

This editorial refers to ‘Left ventricular outflow tract obstruction and sudden death risk in patients with hypertrophic cardiomyopathy’{dagger} by P. Elliott et al., on page 1933

The first 10% of the full text of this article appears below.

Hypertrophic cardiomyopathy (HCM) is the most common genetic heart disease, as well as the most frequent cause of sudden cardiac death in young people including competitive athletes.1 The devastating consequence of sudden death has, in fact, been central to our perception of the natural history of HCM for almost 50 years, as its initial contemporary description by Teare in 1958.1 Now that HCM has assumed an important place in the implantable cardioverter-defibrillator (ICD) era,2 the issue of risk stratification and sudden death prevention has become a major clinical consideration and central to the management of these patients, adding enormously to the complexity of the disease.

Indeed, the ICD was initially promoted specifically for HCM in 20002, and subsequently thousands of young patients have been afforded this potentially life-saving therapy. The efficacy of the ICD in HCM, for both secondary and primary prevention, is now well established.2,3 Despite this . . . [Full Text of this Article]


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Related articles in EHJ:

Left ventricular outflow tract obstruction and sudden death risk in patients with hypertrophic cardiomyopathy
Perry M. Elliott, Juan R. Gimeno, María T. Tomé, Jaymin Shah, Deirdre Ward, Rajesh Thaman, Jens Mogensen, and William J. McKenna
EHJ 2006 27: 1933-1941. [Abstract] [Full Text]  



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B. J. Maron, I. Olivotto, and M. S. Maron
Left ventricular outflow tract obstruction and sudden death in hypertrophic cardiomyopathy: reply
Eur. Heart J., December 2, 2006; 27(24): 3073 - 3074.
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