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European Heart Journal Advance Access originally published online on August 9, 2006
European Heart Journal 2006 27(18):2147-2149; doi:10.1093/eurheartj/ehl170
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© The European Society of Cardiology 2006. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Delayed neointimal healing after drug-eluting stent implantation: seeing is believing

Walter Desmet

Department of Cardiology, University Hospital Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium

Corresponding author. Tel: +32 16 344 235. E-mail address: walter.desmet@uz.kuleuven.ac.be

This editorial refers to ‘Angioscopic differences in neointimal coverage and in persistence of thrombus between sirolimus-eluting stents and bare metal stents after a 6-month implantation’{dagger} by Takano et al., on page 2189

The first 150 words of the full text of this article appear below.

Ever since its introduction in 1977, the long-term benefit of percutaneous coronary intervention has been limited by the phenomenon of restenosis, i.e. recurrence of significant stenosis at the site of intervention. Whereas, after plain balloon angioplasty, restenosis is for roughly two-thirds due to negative vessel wall remodelling, the late lumen loss after stent implantation is virtually exclusively caused by neointimal hyperplasia, a proliferation of smooth muscle cells with deposition of abundant extracellular matrix. Over the last years, a multitude of anti-proliferative drugs have been tested, several of which have been found effective in inhibiting this neointimal hyperplasia when locally delivered from a polymer-encapsulated stent. The two compounds with the largest clinical experience are paclitaxel and sirolimus, a cytostatic macrocyclic lactone with both anti-inflammatory and anti-proliferative properties.

Although the efficacy of these drug-eluting stents (DES) in preventing restenosis has been well established over the last years, recently, concerns have been raised . . . [Full Text of this Article]


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Related articles in EHJ:

Angioscopic differences in neointimal coverage and in persistence of thrombus between sirolimus-eluting stents and bare metal stents after a 6-month implantation
Masamichi Takano, Takayoshi Ohba, Shigenobu Inami, Koji Seimiya, Shunta Sakai, and Kyoichi Mizuno
EHJ 2006 27: 2189-2195. [Abstract] [FREE Full Text]