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European Heart Journal Advance Access originally published online on September 11, 2006
European Heart Journal 2006 27(19):2263-2265; doi:10.1093/eurheartj/ehl246
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© The European Society of Cardiology 2006. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Leptin and vascular function: friend or foe?

Robert Wolk1,2 and Virend K. Somers1,*

1 Division of Cardiovascular Diseases, Mayo Clinic, 200 First Street, SW, Rochester, MN 55902, USA
2 Pfizer, Global Research and Development, Groton, CT, USA

* Corresponding author. Tel: +1 507 255 1144; fax: +1 507 255 7070. E-mail address: somers.virend@mayo.edu

This editorial refers to ‘Leptin is an endothelial independent vasodilator in humans with coronary artery disease: evidence for tissue specificity of leptin resistance’{dagger} by A.U. Momin et al., on page 2294

The first 10% of the full text of this article appears below.

Leptin is the protein product of the adipocyte ob gene. Leptin levels are related to the amount of body fat, and leptin was viewed primarily as a modulator of appetite control and energy homeostasis. However, leptin receptors have been also identified in various peripheral tissues, including in the cardiovascular system and in human coronary arteries. Although the exact role of leptin in cardiac and vascular homeostasis is still not fully understood, most clinical studies consistently support the notion of leptin as a cardiovascular risk factor, with higher leptin levels associated with worse cardiovascular prognosis.

For example, two nested case-referent studies reported that leptin might be a risk factor for myocardial infarction and stroke.1,2 Although no association between leptin levels and coronary . . . [Full Text of this Article]


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Related articles in EHJ:

Leptin is an endothelial-independent vasodilator in humans with coronary artery disease: evidence for tissue specificity of leptin resistance
Aziz U. Momin, Narbeh Melikian, Ajay M. Shah, David J. Grieve, Stephen B. Wheatcroft, Lindsay John, Ahmed El Gamel, Jatin B. Desai, Toby Nelson, Catherine Driver, Roy A. Sherwood, and Mark T. Kearney
EHJ 2006 27: 2294-2299. [Abstract] [Full Text]  



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[Abstract] [Full Text] [PDF]