European Heart Journal Advance Access originally published online on September 7, 2006
European Heart Journal 2006 27(19):2266-2268; doi:10.1093/eurheartj/ehl248
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© The European Society of Cardiology 2006. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org
Adiponectin and myocardial infarction: a paradox or a paradigm?
1 Division of Cardiac Surgery, St Michael's Hospital, Toronto, Ontario, Canada
2 Division of Cardiology, North York General Hospital, Toronto, Ontario, Canada
3 Department of General Internal Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada
* Corresponding author. Tel: +1 416 782 0092; fax: +1 416 782 0096. E-mail address: subodh.verma@sympatico.ca
This editorial refers to ‘Adiponectin is an independent predictor of all-cause mortality, cardiac mortality, and myocardial infarction in patients presenting with chest pain’
by E. Cavusoglu et al., on page 2300
| The first 150 words of the full text of this article appear below. |
Once considered a disease of the affluent, obesity now prevails in the poorer developing nations as well.1 Although it is widely acknowledged that obesity, together with its allied metabolic disorders, is closely associated with the pathogenesis of cardiovascular diseases (CVDs),1,2 the precise molecular links between obesity and CVD remain speculative. It is evident that adipose tissue, traditionally viewed as a passive energy reservoir, plays a role in homeostasis and metabolism. Adipose tissue has autocrine, paracrine, and endocrine functions and synthesizes and releases a wide array of cytokine-like products collectively termed adipokines. Adipokines include pro- and anti-inflammatory molecules, complement factors, growth factors, and signalling proteins2 that modulate inflammatory, metabolic, and cardiovascular events.2
Adiponectin is an adipocyte-specific protein that circulates in concentrations greater than any other hormone in the body. In contrast to many of the other adipokines, adiponectin appears to offer cardiovascular and metabolic protection via insulin sensitizing, anti-inflammatory, lipid metabolism,
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Related articles in EHJ:
- Adiponectin is an independent predictor of all-cause mortality, cardiac mortality, and myocardial infarction in patients presenting with chest pain
- Erdal Cavusoglu, Cyril Ruwende, Vineet Chopra, Sunitha Yanamadala, Calvin Eng, Luther T. Clark, David J. Pinsky, and Jonathan D. Marmur
EHJ 2006 27: 2300-2309.[Abstract] [Full Text]
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