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European Heart Journal Advance Access originally published online on November 8, 2005
European Heart Journal 2006 27(2):125-126; doi:10.1093/eurheartj/ehi641
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© The European Society of Cardiology 2005. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Coronary endothelial dysfunction following sirolimus-eluting stent placement: should we worry about it?

Amir Lerman1 and Eric Eeckhout2,*

1Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo College of Medicine, 200 First Street, SW Rochester, MN 55902, USA
2Cardiology Service, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland

* Corresponding author. Tel: +41 21 3140010; fax: +41 21 3140067. E-mail address: eric.eeckhout@chuv.ch

This editorial refers to ‘Indication of long-term endothelial dysfunction after sirolimus-eluting stent implantation’{dagger} by S.H. Hofma et al., on page 166

The first 10% of the full text of this article appears below.

Hofma et al.1 report the presence of abnormal coronary vasoconstriction to the endothelium-dependent vasodilator acetylcholine distally to the site of sirolimus-eluting stent (SES) implantation. The investigators prospectively studied 15 patients undergoing stenting for a single de novo lesion: nine with a SES and six with a bare metal stent (BMS). Coronary endothelial function was assessed at baseline and 6 months follow-up. The presence of abnormal coronary flow reserve or anatomical differences between the groups was ruled out by the coronary flow response to adenosine using intracoronary Doppler and by intravascular ultrasound, respectively. There was significantly more distal epicardial vasoconstriction to acetylcholine in the SES when compared with the BMS group. The authors concluded that SES might have an adverse effect on local coronary endothelial function. The current study compliments a recent report from Togni . . . [Full Text of this Article]

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Related articles in EHJ:

Indication of long-term endothelial dysfunction after sirolimus-eluting stent implantation
Sjoerd H. Hofma, Wim J. van der Giessen, Bas M. van Dalen, Pedro A. Lemos, Eugene P. McFadden, Georgios Sianos, Jurgen M.R. Ligthart, Dirk van Essen, Pim J. de Feyter, and Patrick W. Serruys
EHJ 2006 27: 166-170. [Abstract] [FREE Full Text]