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European Heart Journal Advance Access originally published online on September 11, 2006
European Heart Journal 2006 27(20):2380-2381; doi:10.1093/eurheartj/ehl247
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© The European Society of Cardiology 2006. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Assessment of ventricular dyssynchrony: global or regional function?

John E. Sanderson*

Department of Cardiology, University Hospital of North Staffordshire NHS Trust, Keele University Medical School, City General Hospital, Stoke-on-Trent ST4 6QG, UK

* Corresponding author. Tel: +44 178255234; fax: +44 1782713071. E-mail address: john.sanderson@uhns.nhs.uk

This editorial refers to ‘Comparison of segmental and global markers of dyssynchrony in predicting clinical response to cardiac resynchronization’{dagger} by A.M. Duncan et al., on page 2426

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A common cliché states that if you stand still every 10 years, you will find yourself in the forefront of fashion. Thus it seems with the analysis of ventricular function. It has been recognized for many years that incoordinate or non-uniform contraction reduces global left ventricular (LV) function. Wiggers demonstrated in 1922 that stimulation from a ventricular focus rather than supraventricular produced a reduced pulse pressure, prolonged isometric contraction, and systolic ejection time in normal hearts. Although regional wall motion abnormalities were recognized early in ischaemic heart disease, it was also demonstrated later that it occurs in dilated or hypertrophic cardiomyopathy.1 However, the realization that asynchronous wall motion due to delayed activation such as in the presence of a left bundle branch block profoundly affected global function did not take place until more recently.2 Developments in cardiac imaging . . . [Full Text of this Article]


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Related articles in EHJ:

Comparison of segmental and global markers of dyssynchrony in predicting clinical response to cardiac resynchronization
Alison M. Duncan, Eric Lim, Jonathan Clague, Derek G. Gibson, and Michael Y. Henein
EHJ 2006 27: 2426-2432. [Abstract] [Full Text]  



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