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European Heart Journal Advance Access originally published online on October 12, 2006
European Heart Journal 2006 27(22):2617-2618; doi:10.1093/eurheartj/ehl310
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© The European Society of Cardiology 2006. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Devices in heart failure: building up the evidence

Frieder Braunschweig

Department of Cardiology, Karolinska University Hospital, S-171 76 Stockholm, Sweden

Corresponding author. Tel: +46 8 51771629; fax: +46 8 311044. E-mail address: frieder.braunschweig@karolinska.se

This editorial refers to ‘Effects of cardiac resynchronization therapy on overall mortality and mode of death: a meta-analysis of randomized controlled trials’{dagger} by M. Rivero-Ayerza et al., on page 2682

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The failing heart suffers not only from alterations in cardiac structure and contractile function but also from severe damage to its electrical system. Conduction disturbances leading to asynchronous atrial and ventricular activation, and rhythm disorders, particularly atrial fibrillation and malignant ventricular arrhythmia, are common and account for a substantial proportion of morbidity and mortality in heart failure. Although the link between conduction abnormalities and left ventricular dysfunction has been established already decades ago, the true magnitude of haemodynamic and clinical detriment associated with cardiac dyssynchrony has not been recognized until recently. Moreover, despite the advances of modern drug treatment, sudden cardiac death (SCD) continues to be the main killer in heart failure, accounting for ~50% of deaths. In this scenario, cardiac resynchronization therapy (CRT) and . . . [Full Text of this Article]


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Related articles in EHJ:

Effects of cardiac resynchronization therapy on overall mortality and mode of death: a meta-analysis of randomized controlled trials
Máximo Rivero-Ayerza, Dominic A.M.J. Theuns, Hector M. Garcia-Garcia, Eric Boersma, Maarten Simoons, and Luc J. Jordaens
EHJ 2006 27: 2682-2688. [Abstract] [FREE Full Text]