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European Heart Journal Advance Access originally published online on November 15, 2006
European Heart Journal 2006 27(24):2919-2920; doi:10.1093/eurheartj/ehl374
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© The European Society of Cardiology 2006. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Hypertension begets hypertrophy begets atrial fibrillation? Insights from yet another sheep model

Paulus Kirchhof1,2,* and Ulrich Schotten2,3

1 Department of Cardiology and Angiology, University Hospital Münster and IZKF Münster, Münster, Germany
2 German Atrial Fibrillation Competence NETwork (AFNET), Germany
3 Department of Physiology, University of Maastricht, Maastricht, Germany

* Corresponding author: Medizinische Klinik und Poliklinik C, Kardiologie und Angiologie, Universitätsklinikum Münster, D-48129 Münster, Germany. Tel: +49 251 8345185; fax: +49 251 8347864. E-mail address: kirchhp@uni-muenster.de

This editorial refers to ‘Atrial electrical and structural abnormalities in an ovine model of chronic blood pressure elevation after prenatal corticosteroid exposure: implications for development of atrial fibrillation’{dagger} by P.M. Kistler et al., on page 3045

The first 10% of the full text of this article appears below.

Atrial fibrillation (AF) affects approximately two million patients in the USA and an equal number in Europe and increases morbidity and mortality in affected patients and population worldwide. Although acute conversion of AF to sinus rhythm can be achieved in almost all patients, therapeutic options to maintain sinus rhythm (repeated cardioversions, anti-arrhythmic drugs, catheter ablation, or surgical procedures) are often ineffective. Understanding the different mechanisms that contribute to AF may guide us towards a more effective ‘rhythm control’ therapy.

Arterial hypertension, found in 65–70% of AF patients1,2 but only in . . . [Full Text of this Article]


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Related articles in EHJ:

Atrial electrical and structural abnormalities in an ovine model of chronic blood pressure elevation after prenatal corticosteroid exposure: implications for development of atrial fibrillation
Peter M. Kistler, Prashanthan Sanders, Miodrag Dodic, Steven J. Spence, Chrishan S. Samuel, ChongXin Zhao, Jennifer A. Charles, Glenn A. Edwards, and Jonathan M. Kalman
EHJ 2006 27: 3045-3056. [Abstract] [Full Text]