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European Heart Journal Advance Access originally published online on November 15, 2005
European Heart Journal 2006 27(3):255-257; doi:10.1093/eurheartj/ehi652
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© The European Society of Cardiology 2005. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Are vascular function measurements ready for the clinic?

Andrew M. Wilson1,2,*

1Cardiovascular Medicine Division, Stanford University Medical Center, Stanford, CA, USA
2Department of Medicine, University of Melbourne, St Vincent's Hospital, Melbourne, Australia

* Corresponding author. Tel: +1 650 723 6141; fax: +1 650 725 1599. E-mail address: awilson@cvmed.stanford.edu

This editorial refers to ‘Flow-mediated changes in pulse wave velocity: a new clinical measure of endothelial function’{dagger} by K.K. Naka et al., on page 302

The first 10% of the full text of this article appears below.

The relevance of vascular function assessments to clinical medicine

Changes in vascular function such as endothelial function and arterial stiffness are key early features in the development of human cardiovascular disease, and non-invasive measures of vascular function have been utilized extensively in clinical research. Many non-invasive indices correlate well with more direct and invasive measures and thus can be applied to large cohorts, potentially outside of a laboratory. As some of these techniques are now available for use outside of a research setting, the clinician is increasingly forced to assess their various merits and the relevance of specific findings in individual patients. Although it is logical to suggest that they may, whether such strategies translate into reduced cardiovascular disease morbidity and mortality in a clinical setting is largely unknown.

Abnormalities can be seen in measures of endothelial function and/or arterial stiffness before overt cardiovascular disease develops and . . . [Full Text of this Article]

Measuring endothelial function in clinical practice

Use of vascular assessments in the clinic

Conclusion

Acknowledgement


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Related articles in EHJ:

Flow-mediated changes in pulse wave velocity: a new clinical measure of endothelial function
Katerina K. Naka, Ann C. Tweddel, Sagar N. Doshi, Jonathan Goodfellow, and Andrew H. Henderson
EHJ 2006 27: 302-309. [Abstract] [Full Text]  



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