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European Heart Journal Advance Access originally published online on January 24, 2006
European Heart Journal 2006 27(7):766-767; doi:10.1093/eurheartj/ehi743
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© The European Society of Cardiology 2006. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Osteopontin, coronary calcification, and cardiovascular events: future diagnostic and therapeutic targets for disease prevention?

Paul Schoenhagen*

Department of Cardiovascular Medicine and Department of Radiology, The Cleveland Clinic Foundation, Cardiovascular Imaging Desk HB-6, 9500 Euclid Avenue, Cleveland, OH 44195, USA

* Corresponding author. Tel: +1 216 445 7579; fax: +1 216 445 6855. E-mail address: schoenp1@ccf.org

This editorial refers to ‘Prognostic significance of plasma osteopontin levels in patients with chronic stable angina’{dagger} by P. Minoretti et al., on page 802

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Minoretti et al.1 describe the independent prognostic significance of plasma osteopontin (OPN). OPN was measured in baseline plasma samples from 799 patients with stable angina pectoris and angiographically documented coronary artery disease (CAD). Participants were prospectively followed for a median of 2.7 years. The primary study endpoint was a composite of non-fatal myocardial infarction and cardiovascular death. Age, number of diseased vessels, and treatment with statins were independent predictors of baseline plasma OPN levels. In univariate analysis, the log-transformed OPN level, levels of C-reactive protein, hypertension, and statin use were associated with future adverse events. Levels of OPN . . . [Full Text of this Article]


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Related articles in EHJ:

Prognostic significance of plasma osteopontin levels in patients with chronic stable angina
Piercarlo Minoretti, Colomba Falcone, Margherita Calcagnino, Enzo Emanuele, Maria P. Buzzi, Enrico Coen, and Diego Geroldi
EHJ 2006 27: 802-807. [Abstract] [FREE Full Text]