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European Heart Journal Advance Access originally published online on April 4, 2006
European Heart Journal 2006 27(9):1013-1015; doi:10.1093/eurheartj/ehi889
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© The European Society of Cardiology 2006. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Interleukin-8: more on the mechanisms of progenitor cells mobilization in acute coronary syndromes

Wojciech Wojakowski1,*, Mariusz Z. Ratajczak2 and Michal Tendera1

1 Third Division of Cardiology, Silesian School of Medicine, 45-47 Ziolowa Street, 40-635 Katowice, Poland
2 Stem Cell Biology Program at James Graham Brown Cancer Center and Department of Medicine, University of Louisville, Louisville, KY 40202, USA

* Corresponding author. Tel: +48 604188669; fax: +48 32 2523930. E-mail address: wojwoj@mp.pl

This editorial refers to ‘Interleukin-8 is associated with circulating CD133+ progenitor cells in acute myocardial infarction’{dagger} by K. Schömig et al., on page 1032

The first 10% of the full text of this article appears below.

In the article published in the current issue of European Heart Journal, Schömig and collaborators identify new humoral factor associated with the release of progenitor cells in acute myocardial infarction (AMI). The article expands current knowledge with regard to mobilization of bone-marrow progenitors in AMI by showing that parallel to already described increase of vascular endothelial growth factor, there is a marked upregulation of interleukin-8 (IL-8) in patients with AMI treated with primary percutaneous coronary intervention (PCI). The increase of IL-8 levels shows the similar time-course as the mobilization of CD133+ cells, moreover plasma concentrations of IL-8 and were shown to be an independent predictor of circulating CD133+ cells number in multivariable regression model that included parameters known to influence the progenitor cell mobilization, such as cardiovascular risk factors, infarct size, . . . [Full Text of this Article]


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Interleukin-8 is associated with circulating CD133+ progenitor cells in acute myocardial infarction
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