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European Heart Journal Advance Access originally published online on May 5, 2007
European Heart Journal 2007 28(10):1187-1189; doi:10.1093/eurheartj/ehm074
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© The European Society of Cardiology 2007. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Cardiac magnetic resonance in pulmonary arterial hypertension: a step in the right direction

Adam Torbicki

Department of Chest Medicine, Institute of Tuberculosis and Lung Diseases, Ul. Plocka 26, 01-138, Warszawa, Poland

Corresponding author. Tel: +48 22 4312114; fax: +48 22 4312414. E-mail address: a.torbicki@igichp.edu.pl

This editorial refers to ‘Prognostic value of right ventricular mass, volume and function in idiopathic pulmonary arterial hypertension’{dagger} by S.A. van Wolferen et al., on page 1250

The first 150 words of the full text of this article appear below.

Pulmonary arterial hypertension as a clinical challenge

Pulmonary arterial hypertension (PAH) is clinically a highly malignant disease. Although pathological changes are limited to the vascular wall, uncontrolled proliferation is mostly directed towards vascular lumen. Pulmonary input impedance usually increases at a rate which cannot be effectively matched by the right ventricular (RV) adaptive mechanisms. A series of consequences including RV dilatation, functional tricuspid regurgitation, decreased pulmonary flow, compromised LV filling, and low systemic cardiac output contribute to a fatal vicious circle. The expected median survival of 2.8 years in conventionally treated idiopathic PAH is indeed similar to that of advanced lung or breast cancer.1

In the last decade, important progress has been made in the understanding of the physiopathology and therapy of this disease. Several drugs interfering with important physiopathological pathways of PAH progression were approved, based on the results of right heart catheterization (RCT).2 None of those therapies permit a cure. Nevertheless, in many patients, it . . . [Full Text of this Article]

Cardiac magnetic resonance as a monitoring tool in pulmonary arterial hypertension

Effects of treatment as assessed with cardiac magnetic resonance

‘Absolute’ prognostic markers in pulmonary arterial hypertension?

A step forward in the understanding of pulmonary arterial hypertension

Cardiac magnetic resonance in pulmonary arterial hypertension: future perspectives


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Related articles in EHJ:

Prognostic value of right ventricular mass, volume, and function in idiopathic pulmonary arterial hypertension
Serge A. van Wolferen, Johannes T. Marcus, Anco Boonstra, Koen M.J. Marques, Jean G.F. Bronzwaer, Marieke D. Spreeuwenberg, Pieter E. Postmus, and Anton Vonk-Noordegraaf
EHJ 2007 28: 1250-1257. [Abstract] [FREE Full Text]  



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CHAPTER 24 Pulmonary Hypertension
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