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European Heart Journal Advance Access originally published online on May 10, 2007
European Heart Journal 2007 28(11):1277-1278; doi:10.1093/eurheartj/ehm157
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© The European Society of Cardiology 2007. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Cardiovascular disease and the elderly: can the evidence base avoid irrelevance?

Pamela N. Peterson1,2 and Frederick A. Masoudi1,2,*

1 Denver Health Medical Center, Denver, CO, USA
2 Colorado Health Outcomes Program, The University of Colorado at Denver and Health Science Center, Mail Stop F443, PO Box 6508, Denver, CO 80045, USA

* Corresponding author. Tel: +1 303 436 5498; fax: +1 303 436 7739. E-mail address: fred.masoudi@uchsc.edu

This editorial refers to ‘Effect of long-term ACE-inhibitor therapy in elderly vascular disease patients’{dagger} by M. Gianni et al., on page 1382

The first 10% of the full text of this article appears below.

Cardiovascular disease (CVD) in the elderly is a problem of rapidly growing importance. The prevalence in CVD in older persons is currently about three-fold that in younger populations.1 Further, with the disproportionate growth of the elderly population worldwide, the numbers of older patients with CVD will expand considerably. Also contributing to the impact of CVD in the elderly is the sharp increase in the risk of adverse CVD outcomes that occurs with increasing age.2 Finally, the greater comorbidity associated with older age contributes to a more complex CVD patient population.3,4 This confluence of factors creates an increasingly urgent need to understand effective strategies to ameliorate the burden of CVD in older persons.

Historically, however, clinical trials in CVD have focused on young populations and those without substantial comorbidity. The limited enrolment of . . . [Full Text of this Article]


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Related articles in EHJ:

Effect of long-term ACE-inhibitor therapy in elderly vascular disease patients
Monica Gianni, Jackie Bosch, Janice Pogue, Jeffrey Probstfield, Gilles Dagenais, Salim Yusuf, and Eva Lonn
EHJ 2007 28: 1382-1388. [Abstract] [FREE Full Text]