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European Heart Journal Advance Access originally published online on June 25, 2007
European Heart Journal 2007 28(14):1676-1677; doi:10.1093/eurheartj/ehm233
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© The European Society of Cardiology 2007. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Does adiponectin resistance exist in chronic heart failure?

Ulrich Kintscher

Center for Cardiovascular Research (CCR), Institute of Pharmacology, Charité – Universitätsmedizin Berlin, Hessische Str. 3–4, 10115 Berlin, Germany

Corresponding author: Tel: +49 304 50525276; fax: +49 304 50525901. E-mail address: ulrich.kintscher@charite.de

This editorial refers to ‘Total and high molecular weight adiponectin, haemodynamics, and mortality in patients with chronic heart failure’ by T. Tsutamoto et al., on page 1723

The first 10% of the full text of this article appears below.

Adiponectin is an adipocytokine, which is mainly expressed in adipose tissue and has been identified as a potent insulin-sensitzing hormone.1 Adiponectin administration lowers glucose levels and ameliorates insulin resistance in mice.1 In humans, plasma levels of adiponectin correlate inversely with visceral fat accumulation and insulin resistance.2 Prospective and longitudinal studies have demonstrated that lower adiponectin levels are closely associated with a higher incidence of type 2 diabetes mellitus.3 In addition, adiponectin exerts pronounced anti-atherogenic and anti-inflammatory actions; therefore, it is not surprising that hypoadiponectinemia has . . . [Full Text of this Article]


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Related articles in EHJ:

Total and high molecular weight adiponectin, haemodynamics, and mortality in patients with chronic heart failure
Takayoshi Tsutamoto, Toshinari Tanaka, Hiroshi Sakai, Chitose Ishikawa, Masanori Fujii, Takashi Yamamoto, and Minoru Horie
EHJ 2007 28: 1723-1730. [Abstract] [Full Text]