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European Heart Journal Advance Access originally published online on July 2, 2007
European Heart Journal 2007 28(15):1785-1786; doi:10.1093/eurheartj/ehm260
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© The European Society of Cardiology 2007. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Link between erythropoietin release and mobilization of endothelial progenitor cells in acute myocardial infarction

Wojciech Wojakowski*, Maciej Kazmierski, Barbara Korzeniowska and Michal Tendera

Third Division of Cardiology, Silesian School of Medicine, 45–47 Ziolowa Street, 40-635 Katowice, Poland [The European Vascular Genomics Network (EVGN)]

* Corresponding author. Tel: +48 604188669; fax: +48 32 2523930. E-mail address: wojwoj@mp.pl

This editorial refers to ‘Early haemoglobin-independent increase of plasma erythropoietin levels in patients with acute myocardial infarction’ by M. Ferrario et al., on page 1805

The first 10% of the full text of this article appears below.

Myocardial infarction (MI) is associated with the increase in plasma levels of inflammatory and haematopoietic cytokines and mobilization of a heterogenous population of cells which consists predominantly of committed lineages (monocytes, polymorphonuclear granulocytes, and lymphocytes), as well as numerous types of stem/progenitor cells [endothelial progenitor cells (EPCs), haematopoietic stem cells (HSCs), and mesenchymal stem cells (MSCs)]. The number of circulating EPCs may have a prognostic value; however, this concept remains to be proved in large prospective studies.1,2 The number of circulating EPCs and mature endothelial cells (ECs) supposedly reflects the vascular endothelial injury and the repair mechanisms activated to restore the endothelial integrity.

The article by Ferrario et al.3 investigates the haemoglobin-independent increase of the . . . [Full Text of this Article]


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Related articles in EHJ:

Early haemoglobin-independent increase of plasma erythropoietin levels in patients with acute myocardial infarction
Maurizio Ferrario, Margherita Massa, Vittorio Rosti, Rita Campanelli, Marco Ferlini, Barbara Marinoni, Gaetano Maria De Ferrari, Valentina Meli, Mara De Amici, Alessandra Repetto, Anna Verri, Ezio Bramucci, and Luigi Tavazzi
EHJ 2007 28: 1805-1813. [Abstract] [FREE Full Text]