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European Heart Journal Advance Access originally published online on July 10, 2007
European Heart Journal 2007 28(16):1923-1924; doi:10.1093/eurheartj/ehm266
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© The European Society of Cardiology 2007. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Apical hypertrophic cardiomyopathy or left ventricular non-compaction? A difficult differential diagnosis

Paolo Spirito1,* and Camillo Autore2

1 Divisione di Cardiologia, Ospedale Galliera, Via Volta 8, 1628 Genoa, Italy
2 Divisione di Cardiologia, Ospedale Sant'Andrea, II Facoltà di Medicina, Università ‘La Sapienza’, Rome, Italy

* Corresponding author. Tel: +39-010-5634170; fax: +39-010-5634180. E-mail address: paolo.spirito@galliera.it

This editorial refers to ‘Mutation in the alpha-cardiac actin gene associated with apical hypertrophic cardiomyopathy, left ventricular non-compaction, and septal defects’ by L. Monserrat et al., on page 1953

The first 10% of the full text of this article appears below.

Hypertrophic cardiomyopathy (HCM) is a familial cardiac disease caused by mutations in one or more of 12 genes encoding protein components of the cardiac sarcomere.1,2 The disease is transmitted with an autosomal dominant trait and a variable penetrance. The phenotypic features of HCM may develop at any age from infancy to adulthood, and are characterized by a great heterogeneity in the extent, magnitude, and distribution of left ventricular (LV) hypertrophy.1 Apical HCM is a relatively rare morphological expression of the disease (<5% of patients), in which LV wall thickening is confined to the most distal portion of the ventricle, below the papillary muscle level.3,4 This form of HCM is more frequently sporadic, but may also be encountered in the . . . [Full Text of this Article]


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Related articles in EHJ:

Mutation in the alpha-cardiac actin gene associated with apical hypertrophic cardiomyopathy, left ventricular non-compaction, and septal defects
Lorenzo Monserrat, Manuel Hermida-Prieto, Xusto Fernandez, Isabel Rodríguez, Carlos Dumont, Laura Cazón, Margarita G. Cuesta, Carlos Gonzalez-Juanatey, Jesús Peteiro, Nemesio Álvarez, Manuel Penas-Lado, and Alfonso Castro-Beiras
EHJ 2007 28: 1953-1961. [Abstract] [Full Text]