European Heart Journal Advance Access originally published online on October 11, 2007
European Heart Journal 2007 28(21):2557-2558; doi:10.1093/eurheartj/ehm371
Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2007. For permissions please email: journals.permissions@oxfordjournals.org
Renin turning full circle as cardiovascular risk factor
1 Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Diseases, University of Leuven, Leuven, Belgium
2 Department of Cardiology, Heart Lung Centre, Radboud University Medical Centre, Nijmegen, The Netherlands
* Corresponding author. E-mail address: jan.staessen@med.kuleuven.be
This editorial refers to Plasma renin and risk of cardiovascular disease and mortality: the Framingham Heart Study by N.I. Parikh et al., on page 2644
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The opinions expressed in this article are not necessarily those of the Editors of the European Heart Journal or of the European Society of Cardiology.
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Renin released from the kidneys, along the cascade of the renin–angiotensin–aldosterone axis, is a major regulator of blood pressure via the generation of angiotensin II and of body sodium and potassium via aldosterone release. Under normal conditions, renin decreases with age and higher blood pressure, whereas salt depletion stimulates renin release. In 1972, Brunner and Laragh first introduced the concept of classifying hypertensive patients according to plasma renin activity in relation to the daily sodium excretion.1 Among patients with essential hypertension, those with normal
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EHJ 2007 28: 2644-2652.[Abstract] [FREE Full Text]