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European Heart Journal Advance Access originally published online on September 28, 2007
European Heart Journal 2007 28(21):2561-2562; doi:10.1093/eurheartj/ehm413
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2007. For permissions please email: journals.permissions@oxfordjournals.org

Exploring new drugs for heart failure: the case of urocortin

W.H. Wilson Tang and Gary S. Francis*

Department of Cardiovascular Medicine, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA

* Corresponding author. Tel: +1 216 444-3410; fax: +1 216 636-0063. E-mail address: francig@ccf.org

This editorial refers to ‘Urocortin 2 infusion in human heart failure’ by M.E. Davis et al., on page 2589

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The opinions expressed in this article are not necessarily those of the Editors of the European Heart Journal or of the European Society of Cardiology.

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Over the past decade, clinical development of natriuretic peptide analogues as drug therapy for acute heart failure has sparked a wide range of interests to seek other endogenous vasoactive peptide systems that are operative as adaptive responders in human heart failure. With rapid advances in the molecular understanding of heart failure pathogenesis, several novel neurohormonal systems have been identified and more are under study. Bringing a potential therapeutic concept from bench to bedside today often involves a prerequisite set of animal and human studies. However, much of the attention in recent years has focused on identifying what the . . . [Full Text of this Article]


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Related articles in EHJ:

Urocortin 2 infusion in human heart failure
Mark E. Davis, Christopher J. Pemberton, Timothy G. Yandle, Steve F. Fisher, John G. Lainchbury, Christopher M. Frampton, Miriam T. Rademaker, and Mark Richards
EHJ 2007 28: 2589-2597. [Abstract] [Full Text]