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European Heart Journal Advance Access originally published online on January 12, 2007
European Heart Journal 2007 28(3):274-275; doi:10.1093/eurheartj/ehl454
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© The European Society of Cardiology 2007. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Adiponectin and risk of acute coronary syndromes: defining the obesity phenotype

Tobias Pischon1,* and Eric B. Rimm2,3,4

1 Department of Epidemiology, German Institute of Human Nutrition (DIfE), Potsdam-Rehbruecke, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany
2 Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
3 Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
4 Channing Laboratory, Department of Medicine, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA

* Corresponding author. Tel: +49 33200 88 710; fax: +49 33200 88 721. E-mail address: pischon@dife.de

This editorial refers to ‘Association between plasma adiponectin levels and unstable coronary syndromes’{dagger} by R. Wolk et al., on page 292

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Obesity is a major risk factor for coronary heart disease (CHD), the leading cause of death worldwide.1 Acute coronary syndromes (ACS), including unstable angina pectoris and myocardial infarction, usually result from acute coronary thrombosis as a product of atherosclerotic CHD. There is no straightforward relationship between plaque size and likelihood of plaque rupture, and angiographic studies have shown that lesions preceding non-fatal acute events are usually not haemodynamically significant.2 Further, the majority of ruptured plaques heals without clinical consequence. Understanding the pathophysiology that leads to CHD in general and to ACS specifically and identifying the risk factors are crucial steps for efforts to prevent these diseases. Obese individuals have an ~1.5–2.0-fold increased risk for CHD, and between 15 and 20% of all cases of CHD can be attributed . . . [Full Text of this Article]


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Related articles in EHJ:

Association between plasma adiponectin levels and unstable coronary syndromes
Robert Wolk, Peter Berger, Ryan J. Lennon, Emmanouil S. Brilakis, Diane E. Davison, and Virend K. Somers
EHJ 2007 28: 292-298. [Abstract] [FREE Full Text]  



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