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European Heart Journal Advance Access originally published online on March 5, 2007
European Heart Journal 2007 28(6):651-652; doi:10.1093/eurheartj/ehm009
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© The European Society of Cardiology 2007. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Bone marrow for cardiac repair: the importance of characterizing the phenotype and function of injected cells

Buddhadeb Dawn and Roberto Bolli*

Division of Cardiology and the Institute of Molecular Cardiology, University of Louisville, Louisville, KY 40292, USA

* Corresponding author. Tel: +1 502 8521837; fax: +1 502 852 6474. E-mail address: rbolli@louisville.edu

This editorial refers to ‘Cell isolation procedures matter: a comparison of different isolation protocols of bone marrow mononuclear cells used for cell therapy in patients with acute myocardial infarction’ {dagger} by F.H. Seeger et al., on page 766

The first 10% of the full text of this article appears below.

Administration of adult stem cells for cardiac repair after myocardial infarction (MI) is a revolutionary new strategy that could become clinically feasible in the near term, appears to be safe and relatively cost-effective, and offers tremendous potential to improve prognosis.1 Using diverse cell populations and strategies, several relatively small clinical studies have reported encouraging outcomes, with improvement in various measures of myocardial perfusion and left ventricular (LV) function.2 However, negative data have also emerged, generating controversy regarding the overall efficacy of cell therapy.2

This controversy persists even after the recent publication of the three largest randomized studies to date of cell therapy for cardiac repair.3–5 In the largest of these trials, the multicentre REPAIR-AMI study,3 204 patients received an intracoronary infusion of autologous mononuclear bone marrow cells (BMCs) or placebo (medium) at 3–7 days . . . [Full Text of this Article]


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Related articles in EHJ:

Cell isolation procedures matter: a comparison of different isolation protocols of bone marrow mononuclear cells used for cell therapy in patients with acute myocardial infarction
Florian H. Seeger, Torsten Tonn, Nicola Krzossok, Andreas M. Zeiher, and Stefanie Dimmeler
EHJ 2007 28: 766-772. [Abstract] [Full Text]  



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