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European Heart Journal Advance Access originally published online on March 30, 2007
European Heart Journal 2007 28(7):780-781; doi:10.1093/eurheartj/ehm024
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© The European Society of Cardiology 2007. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Metabolic syndrome: nothing more than a constellation?

Valérie Tikhonoff* and Edoardo Casiglia

Department of Clinical and Experimental Medicine, University of Padova, Via Giustiniani, 2, I-35128 Padova, Italy

* Corresponding author. Tel: +39 (0) 49 8212273; fax: +39 (0) 49 8754179. E-mail address: valerie.tikhonoff@unipd.it

This editorial refers to ‘The metabolic syndrome predicts cardiovascular mortality: a 13-year follow-up study in elderly non-diabetic Finns’{dagger} by J. Wang et al., on page 857

The first 10% of the full text of this article appears below.

In these last years, the scientific community made a considerable effort to understand the biology underlying cardiovascular disease (CVD), the major cause of morbidity and mortality in the developed world. From the very beginning it became apparent that several CVD risk factors were present in the same individual, and the concept of clustering risk factors was finally labelled in the 1980s by Reaven as ‘Syndrome X’.1 This author postulated that a set of metabolic and cardiovascular risk factors—such as hypertension, hypertriglyceridaemia, low high-density lipoprotein (HDL)-cholesterol levels, and hyperinsulinaemia—could have a common aetiology based on insulin resistance, this latter also playing per se a pivotal role on pathophysiology of CVD. Since then, several other features were taken into account . . . [Full Text of this Article]


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Related articles in EHJ:

The metabolic syndrome predicts cardiovascular mortality: a 13-year follow-up study in elderly non-diabetic Finns
Jianjun Wang, Sanna Ruotsalainen, Leena Moilanen, Päivi Lepistö, Markku Laakso, and Johanna Kuusisto
EHJ 2007 28: 857-864. [Abstract] [Full Text]