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European Heart Journal Advance Access originally published online on March 30, 2007
European Heart Journal 2007 28(8):915-917; doi:10.1093/eurheartj/ehm045
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© The European Society of Cardiology 2007. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Fibrinolysis may widen the time window for primary angioplasty

Tomasz Siminiak1,* and Dariusz Dudek2

1 Poznan University School of Medical Sciences, Cardiac and Rehabilitation Hospital Kowanówko, ul. Sanatoryjna 34, 64–600 Kowanówko k/Obornik Wlkp. Poland
2 Department of Interventional Cardiology, Jagiellonian University Medical College, Krakow, Poland

* Corresponding author. Tel: +48 602217202; fax: +48 612977500. E-mail address: tomasz.siminiak@usoms.poznan.pl

This editorial refers to ‘Primary angioplasty vs. early routine post-fibrinolysis angioplasty for acute myocardial infarction with ST-segment elevation: the GRACIA-2 non-inferiority, randomized, controlled trial’{dagger} by F. Fernández-Avilés et al., on page 949

The first 150 words of the full text of this article appear below.

Recently published clinical trials have demonstrated superiority of primary percutaneous coronary intervention (PPCI) over lysis in ST-elevation myocardial infarction (STEMI) treatment. Current practice guidelines1 have established PPCI as a preferred method of reperfusion in STEMI, as long as it can be performed within 90 min from patient's first medical contact. However, in the majority of cases achieving this 90 min time goal proves impossible, mainly because the STEMI care is not streamlined enough between different levels and components of health care system. Accordingly, the optimization of treatment strategy in STEMI patients, who for one reason or another exceed the 90 min delay, is one of the hottest topics in cardiology today. The GRACIA-2 study is certainly an important contribution to that issue.

Clinical trials with lytics have shown a significant correlation between the time of their administration after the symptoms onset and the mortality. First studies with primary PCI demonstrated . . . [Full Text of this Article]


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Related articles in EHJ:

Primary angioplasty vs. early routine post-fibrinolysis angioplasty for acute myocardial infarction with ST-segment elevation: the GRACIA-2 non-inferiority, randomized, controlled trial
Francisco Fernández-Avilés, Joaquín J. Alonso, Gonzalo Peña, Jesús Blanco, Juan Alonso-Briales, Juan López-Mesa, Felipe Fernández-Vázquez, José Moreu, Rosa A. Hernández, Alfonso Castro-Beiras, Rafael Gabriel, C. Michael Gibson, Pedro L. Sánchez, and for the GRACIA-2 (Grupo de Análisis de la Cardiopatía Isquémica Aguda) Investigators
EHJ 2007 28: 949-960. [Abstract] [Full Text]