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European Heart Journal Advance Access originally published online on April 4, 2007
European Heart Journal 2007 28(8):922-923; doi:10.1093/eurheartj/ehl325
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© The European Society of Cardiology 2007. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Monitoring of therapeutic effect in heart failure patients: a clinical application of 123I MIBG imaging?

Maureen M. Henneman, Jeroen J. Bax and Ernst E. van der Wall*

Department of Cardiology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands

* Corresponding author. Tel: +31 71 526 2020; fax: +31 71 526 6809. E-mail address: e.e.van_der_wall@lumc.nl

This editorial refers to ‘Evaluation of cardiac sympathetic nerve activity and left ventricular remodelling in patients with dilated cardiomyopathy on the treatment containing carvedilol’{dagger} by S. Kasama et al., on page 989

The first 10% of the full text of this article appears below.

Labelling of metaiodobenzylguanidine (MIBG) with 123I allows scintigraphic visualization of the cardiac sympathetic nervous system and 123I MIBG was the first radiopharmaceutical that allowed imaging of cardiac neurotransmission by single photon emission computed tomography. Norepinephrine (NE) is the major neurotransmitter of the sympathetic nervous system. 123I MIBG, an analogue of NE, and NE have similar molecular structures, and use the same uptake and storage mechanisms in the pre-synaptic sympathetic nerve ending. Uptake-1 is the most important uptake mechanism of MIBG in human, and is sodium- and energy-dependent. Other uptake mechanisms are the non-neuronal uptake-2 mechanism, which is sodium- and energy-independent, and diffusion.

The cardiac sympathetic nervous system is mainly involved in preserving circulatory homeostasis during environmental stress. Increase of sympathetic nervous activity or a rise in . . . [Full Text of this Article]


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Related articles in EHJ:

Evaluation of cardiac sympathetic nerve activity and left ventricular remodelling in patients with dilated cardiomyopathy on the treatment containing carvedilol
Shu Kasama, Takuji Toyama, Takashi Hatori, Hiroyuki Sumino, Hisao Kumakura, Yoshiaki Takayama, Shuichi Ichikawa, Tadashi Suzuki, and Masahiko Kurabayashi
EHJ 2007 28: 989-995. [Abstract] [FREE Full Text]