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European Heart Journal Advance Access originally published online on April 25, 2007
European Heart Journal 2007 28(9):1049-1051; doi:10.1093/eurheartj/ehm039
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© The European Society of Cardiology 2007. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

Seeing is believing: acute haemodynamic response to predict long-term outcome in cardiac resynchronization therapy

Anil-Martin Sinha1 and Ole-Alexander Breithardt2,*

1 Department of Cardiology, Klinikum Coburg, Coburg, Germany
2 Department of Cardiology, University Hospital, Ulmenweg 18, DE-91054 Erlangen, Germany

* Corresponding author. Tel: +49 9131 85 35301; fax: +49 9131 85 35303. E-mail address: olebreithardt@gmx.de

This editorial refers to ‘Echocardiographic measures of acute haemodynamic response after cardiac resynchronization therapy predict long-term clinical outcome’{dagger} by F.B. Tournoux et al., on page 1143

The first 150 words of the full text of this article appear below.

‘An acute hemodynamic study ... was performed prior to the implant, which demonstrated a significant increase in cardiac output and decrease of pulmonary capillary wedge pressure’ (1)

Many heart failure specialists still believe that the pathophysiology of cardiac resynchronization therapy (CRT) is incompletely understood; however, it must be emphasized that the main effects of biventricular pacing have already been described more than a decade ago.1 In 1994, Cazeau et al.1 reported how biventricular pacing improves clinical signs and symptoms of heart failure, acutely increases cardiac output and decreases pulmonary capillary wedge pressure and that those effects were likely mediated by better synchronization of left ventricular (LV) mechanical contraction. However, despite the obvious clinical success of this novel therapeutic approach, the authors were very modest with speculations on the impact on mortality:

‘We doubt that this technique will have an impact on long-term survival, but it could be of major importance . . . [Full Text of this Article]


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Related articles in EHJ:

Echocardiographic measures of acute haemodynamic response after cardiac resynchronization therapy predict long-term clinical outcome
Francois B. Tournoux, Chrisfouad Alabiad, Dali Fan, Annabel A. Chen, Miguel Chaput, Edwin Kevin Heist, Theofanie Mela, Moussa Mansour, Vivek Reddy, Jeremy N. Ruskin, Michael H. Picard, and Jagmeet P. Singh
EHJ 2007 28: 1143-1148. [Abstract] [FREE Full Text]