European Heart Journal Advance Access originally published online on July 10, 2008
European Heart Journal 2008 29(16):1927-1929; doi:10.1093/eurheartj/ehn321
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org
Acute and stable coronary heart disease: different risk factors
Department of Medicine, Aker University Hospital and Oslo University, 0514 Oslo, Norway
* Corresponding author. Tel: + 47 228 94655, Fax: + 47 228 94259, Email: stefan.agewall@medisin.uio.no
This editorial refers to Contribution of novel biomarkers to incident stable angina and acute coronary syndrome: the PRIME Study
by J.-P. Empana et al., on page 1966
Footnotes
The opinions expressed in this article are not necessarily those of the Editors of the European Heart Journal or of the European Society of Cardiology.
| The first 10% of the full text of this article appears below. |
Coronary heart disease (CHD) continues to be a worldwide leading cause of death for both men and women. When coronary atherosclerosis progresses, there is deposition of plaque external to the lumen of the artery, thus the plaque may extend eccentrically and outward without compromising the lumen initially. As atherosclerosis worsens the plaque mass may later on bulge into the lumen and may therefore result in a haemodynamic obstruction and angina pectoris symptoms. Typically, angina pectoris develops when an atherosclerotic plaque obstructs at least 70% of the arterial lumen. Thus, stable angina pectoris is a condition in which there is regional myocardial ischaemia caused by inadequate coronary perfusion and is usually induced by increases in myocardial oxygen requirements. Chest pain that
Same disease or two different diseases?
Classical cardiovascular risk factors
Inflammation
The endothelium
von Willebrand factor
Interpretation of the study
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Related articles in EHJ:
- Contribution of novel biomarkers to incident stable angina and acute coronary syndrome: the PRIME Study
- Jean-Philippe Empana, Florence Canoui-Poitrine, Gerald Luc, Irene Juhan-Vague, Pierre Morange, Dominique Arveiler, Jean Ferrieres, Philippe Amouyel, Annie Bingham, Michelle Montaye, Jean-Bernard Ruidavets, Bernadette Haas, Alun Evans, Pierre Ducimetiere, and on behalf of the PRIME Study Group
EHJ 2008 29: 1966-1974.[Abstract] [FREE Full Text]