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European Heart Journal Advance Access originally published online on August 1, 2008
European Heart Journal 2008 29(17):2067-2069; doi:10.1093/eurheartj/ehn343
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

Atrial fibrillation is associated with impaired cognitive function and hippocampal atrophy: silent cerebral ischaemia vs. Alzheimer's disease?

Andreas Goette* and Ruediger C. Braun-Dullaeus

Division of Cardiology, University Hospital Magdeburg, D-39120 Magdeburg, Germany

* Corresponding author. Tel: +49 391 6713225, Fax: +49 391 6713202, Email: andreas.goette@medizin.uni-magdeburg.de

This editorial refers to ‘Atrial fibrillation in stroke-free patients is associated with memory impairment and hippocampal atrophy’{dagger} by S. Knecht et al., on page 2125

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The opinions expressed in this article are not necessarily those of the Editors of the European Heart Journal or of the European Society of Cardiology.

The first 10% of the full text of this article appears below.

Atrial fibrillation (AF) is the most common cause of thromboembolic stroke. Several studies have shown an activation of the plasmatic and cellular clotting system in patients with AF.1,2 Interestingly, these changes occur within hours after initiation of AF. In order to predict the individual risk for AF-related thromboembolic events, the CHADS2-score has been developed.1 It takes into account that especially elderly patients, patients with diabetes, hypertension, heart failure, and/or previous stroke are at greatest risk. Depending on the CHADS2-score, the yearly risk of stroke may vary between 1.9% (CHADS2-score of 0) and 18.2% (CHADS2-score of 6). The pathophysiological basis of how these clinical . . . [Full Text of this Article]


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Related articles in EHJ:

Atrial fibrillation in stroke-free patients is associated with memory impairment and hippocampal atrophy
Stefan Knecht, Christian Oelschläger, Thomas Duning, Hubertus Lohmann, Johannes Albers, Christoph Stehling, Walter Heindel, Günter Breithardt, Klaus Berger, E. Bernd Ringelstein, Paulus Kirchhof, and Heike Wersching
EHJ 2008 29: 2125-2132. [Abstract] [FREE Full Text]