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European Heart Journal Advance Access originally published online on September 18, 2008
European Heart Journal 2008 29(20):2451-2452; doi:10.1093/eurheartj/ehn425
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

The measurement of plasma aldosterone in patients post-myocardial infarction

Bertram Pitt*

University of Michigan School of Medicine, Ann Arbor, MI 48109, USA

* Corresponding author. Tel: +1 734 936-5260, Fax: +1 734 936 5256. Email: bpitt@umich.edu

This editorial refers to ‘Plasma aldosterone levels during hospitalization are predictive of survival post-myocardial infarction’{dagger} by B.R. Palmer et al., on page 2489


Footnotes

The opinions expressed in this article are not necessarily those of the Editors of the European Heart Journal or of the European Society of Cardiology.

{dagger} doi:10.1093/eurheartj/ehn383 Back

The first 10% of the full text of this article appears below.

Aldosterone blockade, or more correctly mineralocorticoid receptor blockade (MRB), when administered between days 3 and 14 in patients with heart failure (HF) and left ventricular systolic dysfunction (LVSD) post-myocardial infarction (MI) has been shown to reduce all-cause mortality as well as hospitalizations for HF (EPHESUS).1 Of note, all-cause mortality was reduced by 31% at 30 days post-randomization.2 These benefits on mortality were seen in patients with an ST-segment elevation (STE) MI and in those with a non-ST-segment elevation (NST) MI, as well as in patients treated with ‘optimal’ medical therapy including an aspirin, statin, reperfusion, a diuretic, a β-adrenergic receptor blocker, and . . . [Full Text of this Article]


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