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European Heart Journal Advance Access originally published online on September 4, 2008
European Heart Journal 2008 29(20):2453-2455; doi:10.1093/eurheartj/ehn393
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

Nitric oxide: the missing lusitrope in failing myocardium

Jean G.F. Bronzwaer1 and Walter J. Paulus2,*

1 Department of Cardiology, Institute for Cardiovascular Research, VU University Medical Center (VUMC), Amsterdam, The Netherlands
2 Department of Physiology, Institute for Cardiovascular Research, VU University Medical Center (VUMC), Amsterdam, The Netherlands

* Corresponding author. Tel: +31 20 4448110, Fax: +31 20 4448255, Email: wj.paulus@vumc.nl

This editorial refers to ‘Differential effects of arginine methylation on diastolic dysfunction and disease progression in patients with chronic systolic heart failure’{dagger} by W.H. Wilson Tang et al., on page 2506

Footnotes

The opinions expressed in this article are not necessarily those of the Editors of the European Heart Journal or of the European Society of Cardiology.

{dagger} doi:10.1093/eurheartj/ehn360 Back

The first 10% of the full text of this article appears below.

During the last decade, the effects of nitric oxide (NO) on contractile function of failing myocardium elicited a lot of interest and research activity. Because of initial reports of NO acutely reducing the extent and velocity of shortening of isolated cardiomyocytes, especially following β-adrenergic stimulation, and because of increased activity of inducible nitric oxide synthase (NOS2) in human cardiomyopathic myocardium, numerous reports and reviews have persistently and erroneously identified NO as deleterious for contractile function of failing myocardium.1 Shortly after these initial reports, a rosier picture of NO's functional myocardial effects emerged, highlighting NO's ability to improve left ventricular (LV) diastolic function. In the normal human heart, intracoronary administration of NO donors instantaneously hastens onset of LV relaxation and . . . [Full Text of this Article]

Microvascular inflammation and diastolic LV dysfunction

Lusitropic actions of NO

Treatment of diastolic LV dysfunction

Conclusions


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Differential effects of arginine methylation on diastolic dysfunction and disease progression in patients with chronic systolic heart failure
Wai Hong Wilson Tang, Wilson Tong, Kevin Shrestha, Zeneng Wang, Bruce S. Levison, Brian Delfraino, Bo Hu, Richard W. Troughton, Allan L. Klein, and Stanley L. Hazen
EHJ 2008 29: 2506-2513. [Abstract] [FREE Full Text]  

Differential effects of arginine methylation on diastolic dysfunction and disease progression in patients with chronic systolic heart failure
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