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European Heart Journal Advance Access originally published online on June 13, 2009
European Heart Journal 2009 30(14):1692-1694; doi:10.1093/eurheartj/ehp239
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org

Muscle sympathetic nerve activity in women and men following acute myocardial infarction: a meaningful difference?

John S. Floras* and Susanna Mak

University Health Network and Mount Sinai Hospital Division of Cardiology, University of Toronto, Toronto, Ontario, Canada

* Corresponding author. Tel: +1 416 586 8704, Fax: +1 416 586 8702, Email: john.floras@utoronto.ca

This editorial refers to ‘Gender differences in sympathetic neural activation following uncomplicated acute myocardial infarction’{dagger}, by A.J. Hogarth et al., on page 1764

The first 10% of the full text of this article appears below.

Awareness of an apparent excess of mortality in women, as compared with men, in the days subsequent to acute myocardial infarction (AMI) prompted Hogarth and colleagues to investigate whether there exist sex-related differences in the magnitude of post-infarct efferent sympathetic nerve discharge.1 In a remarkable technical tour de force, these investigators quantified the frequency of fibular nerve muscle sympathetic single- and multifibre discharge [muscle sympathetic nerve activity (MSNA)]in a cohort of 72 carefully assembled Caucasian subjects, divided equally between women and men suffering an uncomplicated acute infarct, and well-matched healthy non-medicated female and male control subjects. Patients were screened by history and laboratory examination to exclude the potential confounding influence of known stimuli to sympathetic excitation or autonomic neuropathy. In study patients, MSNA and pre-specified haemodynamic and autonomic variables were acquired on four separate occasions: 2–4 days, and 3, 6, and . . . [Full Text of this Article]


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Related articles in EHJ:

Gender differences in sympathetic neural activation following uncomplicated acute myocardial infarction
Andrew J. Hogarth, Lee N. Graham, David A.S.G. Mary, and John P. Greenwood
EHJ 2009 30: 1764-1770. [Abstract] [Full Text]