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European Heart Journal Advance Access originally published online on September 22, 2009
European Heart Journal 2009 30(21):2551-2553; doi:10.1093/eurheartj/ehp383
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that the original authorship is properly and fully attributed; the Journal, Learned Society and Oxford University Press are attributed as the original place of publication with correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oxfordjournals.org

MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial–Cardiac Resynchronization Therapy): cardiac resynchronization therapy towards early management of heart failure

Günter Breithardt*

Medizinische Klinik und Poliklinik C (Kardiologie/Angiologie), Universitätsklinikum Münster, D-48129 Münster, Germany

* Corresponding author. Tel: +49 251 86 88 21, Fax: +49 251 86 88 22, Email: g.breithardt@uni-muenster.de

The first 150 words of the full text of this article appear below.

This commentary refers to ‘Cardiac-resynchronization therapy for the prevention of heart-failure events’{dagger}, by A.J. Moss et al., published in the New England Journal of Medicine, 2009; 361:1329–1338

Randomized clinical trials have firmly established the role of cardiac resynchronization therapy (CRT) in chronic heart failure patients in New York Heart Association (NYHA) class III or IV who have left ventricular dysfunction and a prolonged QRS complex. CRT improves symptoms, reduces the need for hospitalizations, and improves survival by reversal of left ventricular remodelling and by slowing of disease progression.

In these CRT trials, patients were selected on the basis of the degree of heart failure. COMPANION1 included 86% class III and 14% class IV patients. CARE-HF included 94% NYHA class III and 6% class IV patients.2 Thus, the data on the beneficial effects of CRT, based on large trials, are restricted to class III and to a . . . [Full Text of this Article]

MADIT-CRT: new evidence for the benefit of CRT

Comparison between REVERSE and MADIT-CRT: the same message?

Open issues

Conclusions

Funding


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