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European Heart Journal Advance Access originally published online on February 27, 2009
European Heart Journal 2009 30(7):752-754; doi:10.1093/eurheartj/ehp081
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org

Body fat and cardiovascular risk: understanding the obesity paradox

Felicita Andreotti*, Teresa Rio and Alberto Lavorgna

Department of Cardiovascular Medicine, Gemelli University Hospital, Largo Gemelli 8, 00168 Rome, Italy

* Corresponding author. Tel. +39 06 30154187, Fax +39 06 3055535, Email: felicita.andreotti@iol.it

This editorial refers to ‘The influence of body mass index on mortality and bleeding among patients with or at high-risk of atherothrombotic disease’{dagger}, by K.-H. Mak et al., on page 857

The first 10% of the full text of this article appears below.

Large studies of initially healthy men and women consistently link adiposity with an increased risk of cardiovascular events.1,2 Compared with a reference body mass index (BMI) <25 kg/m2, the relative risk of dying during the next decade ranges from 1.2 for overweight (25–29.9 kg/m2) to 3.8 for severely obese (≥40 kg/m2) subjects, after adjustment for age, smoking, alcohol, and physical activity.1 Abdominal fat, measured as the waist–hip ratio, more reliably predicts the risk of ischaemic heart disease and death than BMI, even within normal body weights and after additional adjustment for blood pressure and cholesterol.2,3

In striking contrast, among patients . . . [Full Text of this Article]


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Related articles in EHJ:

The influence of body mass index on mortality and bleeding among patients with or at high-risk of atherothrombotic disease
Koon-Hou Mak, Deepak L. Bhatt, Mingyuan Shao, Steven M. Haffner, Christian W. Hamm, Graeme J. Hankey, S. Claiborne Johnston, Gilles Montalescot, Philippe Gabriel Steg, Steven R. Steinhubl, Keith A.A. Fox, and Eric J. Topol
EHJ 2009 30: 857-865. [Abstract] [Full Text]