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European Heart Journal 2002 23(19):1482-1484; doi:10.1053/euhj.2002.3347
Copyright © 2002 by the European Society of Cardiology.
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Editorials

Homocysteine and vascular disease

K. Robinson

Department of Cardiology, Wake Forest University School of Medicine, Winston Salem, NC, U.S.A.

References

  1. Selhub J, Jacques PF, Wilson PW, Rush D, Rosenberg IH. Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. JAMA. 1993;270:2693–2698[Abstract]
  2. Wilcken DE, Reddy SG, Gupta VJ. Homocysteinemia, ischemic heart disease, and the carrier state for homocystinuria. Metab Clin Exper. 1983;32:363–370[CrossRef][ISI][Medline]
  3. Boers GH, Smals AG, Trijbels FJ. Heterozygosity for homocystinuria in premature peripheral and cerebral occlusive arterial disease. N Engl J Med. 1985;313:709–715[Abstract]
  4. Brattstrom L, Israelsson B, Norrving B. Impaired homocysteine metabolism in early-onset cerebral and peripheral occlusive arterial disease. Effects of pyridoxine and folic acid treatment. Atherosclerosis. 1990;81:51–60[CrossRef][ISI][Medline]
  5. Anonymous. Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials. Homocysteine Lowering Trialists' Collaboration. BMJ. 1998;316:894–898[Abstract/Free Full Text]
  6. Ward M, McNulty H, McPartlin J, Strain JJ, Weir DG, Scott JM. Plasma homocysteine, a risk factor for cardiovascular disease, is lowered by physiological doses of folic acid. QJM. 1997;90:519–524[Abstract/Free Full Text]
  7. Wald DS, Bishop L, Wald NJ. Randomized trial of folic acid supplementation and serum homocysteine levels. Arch Int Med. 2001;161:695–700[Abstract/Free Full Text]
  8. Chait A, Malinow MR, Nevin DN. Increased dietary micronutrients decrease serum homocysteine concentrations in patients at high risk of cardiovascular disease. Am J Clin Nutr. 1999;70:881–887[Abstract/Free Full Text]
  9. Appel LJ, Miller ER, Jee SH. Effect of dietary patterns on serum homocysteine: results of a randomized, controlled feeding study. Circulation. 2000;102:852–857[Abstract/Free Full Text]
  10. Malinow MR, Duell PB, Hess Dl. Reduction of plasma homocyst(e)ine levels by breakfast cereal fortified with folic acid in patients with coronary heart disease. N Engl J Med. 1998;338:1009–1015[Abstract/Free Full Text]
  11. Jacques PF, Selhub J, Bostom AG, Wilson PW, Rosenburg IH. The effect of folic acid fortification on plasma folate and total homocysteine concentrations. N Engl J Med. 1999;240:1449–1454
  12. Doshi SN, McDowell IF, Moat SJ. Folic acid improves endothelial function in coronary artery disease via mechanisms largely independent of homocysteine lowering. Circulation. 2002;105:22–26[Abstract/Free Full Text]
  13. The PACIFIC Study
  14. Schnyder G, Roffi M, Pin R. Decreased rate of coronary restenosis after lowering of plasma homocysteine levels. N Engl J Med. 2001;345:1593–1600[Abstract/Free Full Text]
  15. Clarke R. An overview of the homocysteine lowering clinical trials. Robinson K. Homocysteine and Vascular Disease. Dordrecht, Boston, London: Kluwer Academic Publishers; 2000.

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This Article
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