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European Heart Journal Advance Access originally published online on April 30, 2007
European Heart Journal 2007 28(10):1269; doi:10.1093/eurheartj/ehm098
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© The European Society of Cardiology 2007. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

The chronic heart failure is not so frequent in non-compaction

Giovanni Fazio

Department of Cardiology
University of Palermo
Via Santa Maria di Gesu' 25
90124 Palermo
Italy

Loredana Sutera

Department of Cardiology
University of Palermo
90124 Palermo
Italy

Giovanni Corrado

Department of Cardiology
Valduce Hospital
Como
Italy

Salvatore Novo

Department of Cardiology
University of Palermo
90124 Palermo
Italy

E-mail address: Giovanni.fazio-aaaa{at}poste.it

Isolated and associated non-compaction of the left ventricle is an uncommon cardiomiopathy, with an unclear natural history.1–3 Some authors described a bad prognosis for this disease.1,2 Instead, other published works, such as the Lilje's1 work published in European heart journal in August, with a longer follow-up and with a larger cohort, reported a medium-long term good prognosis. Correlated with the prognosis is the ventricular dysfunction.

During this last year, we collected more than 230 patients in the Italian society of cardiovascular ultrasound registry. The incidence of chronic heart failure (EF < 45%) in our experience was around 50%. However, an important bias influences these data: all patients enrolled in a hospital division, where, in a large percentage, were admitted for symptoms. So the analysed population is a selected population. To demonstrate this hypothesis, we studied all first-degree relatives of 31 patients. In total, we observed 48 relatives affected by non-compaction. Of the total patients, 61% (19/31) presented an EF reduction, whereas of the relatives, only 2% (1/48) presented an EF reduction.

In our opinion, high incidence described by Lilje et al.1 of ventricular dysfunction is a consequence for a selected cohort.

References

  1. Lilje C, Razek V, Joyce JJ, Rau T, Finckh BF, Weiss F, Rice JC, Weil J. Complications of non-compaction of the left ventricular myocardium in a paediatric population: a prospective study. Eur Heart J (2006) 27:1855–1860.[Abstract/Free Full Text]
  2. Ritter M, Oechslin E, Sutsch G, Attenhofer C, Schneider J, Jenni R. Isolated noncompaction of the myocardium in adults. Mayo Clin Proc (1997) 72:26–31.[Abstract]
  3. Murphy RT, Thaman R, Blanes JG, Ward D, Sevdalis E, Papra E, Kiotsekolglou A, Tome MT, Pellerin D, McKenna WJ, Elliott PM. Natural history and familial characteristics of isolated left ventricular non-compaction. Eur Heart J (2005) 26:187–192.[Abstract/Free Full Text]

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Am. J. Roentgenol., April 1, 2008; 190(4): W274 - W274.
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This Article
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