European Heart Journal Advance Access originally published online on May 3, 2007
European Heart Journal 2007 28(14):1782-1783; doi:10.1093/eurheartj/ehm139
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Early decrease in coagulation activity after myocardial infarction is associated with lower risk of new ischaemic events: observations from the ESTEEM trial
Institute of Cardiology
John Radcliffe Hospital
Oxford
UK
Policlinico Gemelli
Institute of Cardiology
Catholic University
Rome 00168
Italy
Institute of Cardiology
John Radcliffe Hospital
Oxford
UK
Division of Cardiology
University of Turin
Turin
Italy
Department of Medicine
Virginia Commonwealth University
Richmond
VA, USA
Institute of Cardiology
Catholic University
Rome 00168
Italy
Antwerp Cardiovascular Institute Middelheim
AZ Middelheim
Antwerp Belgium
Tel: +44 1865 228934 Fax: +44 1865 220585 E-mail address: luctes{at}gmail.com
We have carefully read the interesting article of Christersson et al.1 focusing on the pivotal issue of risk stratification and prognosis in patients recovering from an acute myocardial infarction (AMI). Analysing data from a cohort of patients enrolled in the ESTEEM trial, the authors aimed at evaluating whether markers for thrombin generation, fibrin turnover, and activated thromboplastin time (APTT) were related to clinical outcomes and whether change in the level of these markers could predict the risk of new ischaemic events or bleedings.2 The authors concluded that in patients with recent AMI a reduction of an initially elevated coagulation activity identifies those at a decreased risk of new ischaemic events, regardless of whether this reduction occurs spontaneously or is induced by pharmacological treatment. In addition, they purported that patients with higher initial coagulation activity may benefit the most from long-term treatment with ximelagatran. Some issues, in our opinion, deserve attention and need a deeper examination in order to avoid possibly misleading conclusions.
Briefly, there were no significant differences in prothrombin fragment 1 + 2 (F1 + 2) and D-dimer levels between the ximelagatran and the placebo groups at randomization. After a week of treatment, in the ximelagatran treated patients, 76% had decreased F1 + 2 level and 72% had decreased D-dimer level, compared with 39 and 40%, respectively, in the placebo group (P < 0.001). Patients with reduction vs. no reduction of F1 + 2 tended to have fewer ischaemic events during the period of randomized treatment (10 vs. 14%), while the group of patients without ischaemic events showed a significantly larger reduction of D-dimer levels than patients with ischaemic events. However, there was no significant interaction (interaction P > 0.05) between changes in coagulation activity and study treatment. Within the cohort of patients with reduced levels of F1 + 2 or D-dimer after 1 week, the frequency of ischaemic events ‘did not significantly differ’ between the ximelagatran group (10 and 8%, P = 0.5) and placebo group (13 and 11%, P = 0.5). At cessation of study treatment (after 6 months) or at premature discontinuation, the median levels for F1 + 2 and D-dimer in the ximelagatran group were still significantly reduced when compared with the placebo group (P < 0.001). However, at follow-up, 2 weeks after cessation of study treatment, the median levels of F1 + 2 and D-dimer had increased in the ximelagatran group and at this time point no significant difference was evident between the ximelagatran and the placebo group.
Given these findings, we agree with the authors when they underline that a reduction of the coagulation markers ‘regardless whether it occurred spontaneously or by ximelagatran treatment’ is associated with a better outcome, in particular at 1-week time point, and that F1 + 2, which reflects thrombin generation, is unlikely to be an useful prognostic marker. On the other hand, D-dimer, reflecting fibrin generation and degradation, appears to be a reliable prognostic marker.
So at odds with the conclusions of the authors, it is conceivable, but ‘not proven’ on the basis of these data, that the addition of ximelagatran on top of the currently available therapies may provide additional benefit in terms of reduction of the coagulation markers: this point is crucial.
At the end of the study, the levels of coagulation markers increased in the ximelagatran group, and we wonder if this increase is significant with respect to the end of the study and to the randomization. Moreover, and this point is completely neglected by the authors, the long-term administration of ximelagatran is bared by prohibitive hepatic toxicity, measured as the rate of alanine aminotransferase (ALT) elevation greater than three times above the upper normal limit.
We have conducted and recently published, a non-biased/non-funded systematic review and a meta-analysis on this topic showing that ximelagratan treatment 
3 months was associated with an OR for hepatotoxicity of 6.73 (95% CI: 5.01–9.05) compared with placebo (P < 0.001). In absolute terms, for prolonged treatments, the incidence of hepatotoxicity rose from 1.1 to 7.1%, with a number needed to harm of 17.3–5 We think that stating that ‘ximelagatran, effectively reduced coagulation activity, and reduced the risk of new ischemic events in patients with high initial coagulation activity’, could be misleading if not weighted against the risk of serious hepatic injury. Indeed, such risk led the FDA to deny approval for ximelagratan in the USA, the EMEA to allow only short-term administration and the manufacturer (Astrazeneca), after a further fatality in a post-marketing study, to withdraw the drug.6–8 In our opinion, even if the aim of the study by Christersson et al. was different, they should have reported, or at least mentioned, possible adverse events related to the study drug.
This study clearly suggests D-dimer as a useful prognostic marker in post-AMI patients, but all the conclusions have to be balanced in a context in which the study drug has been judged unsafe.
References
- Christersson C, Oldgren J, Bylock A, Siegbahn A, Wallentin L. Early decrease in coagulation activity after myocardial infarction is associated with lower risk of new ischaemic events: observations from the ESTEEM trial. In: Eur Heart J (2007) Published online ahead of print February 21.
- Wallentin L, Wilcox RG, Weaver WD, Emanuelsson H, Goodvin A, Nystrom P, Bylock A. Oral ximelagatran for secondary prophylaxis after myocardial infarction: the ESTEEM randomised controlled trial. Lancet (2003) 362:789–797.[CrossRef][Web of Science][Medline]
- Testa L, Andreotti F, Biondi Zoccai GGL, Burzotta F, Bellocci F, Crea F. Ximelagatran/melagatran against conventional anticoagulation: a meta-analysis based on 22639 patients. In: Int J Cardiol (2007) in press.
- Testa L, Biondi-Zoccai GGL, Porto I, Andreotti F, Crea F. The direct thrombin inhibitor Ximelagatran/melagatran: a systematic review on clinical applications and an evidence based assessment of risk benefit profile. In: Exp Opin Drug Metab Toxicol (2007) in press.
- Testa L, Andreotti F, Trotta G, Biondi Zoccai GGL, Burzotta F, Bellocci F, Crea F. Ximelagatran/melagatran versus conventional anticoagulant therapy: meta-analysis of 13 randomised controlled trials enrolling 22639 patients. European Society of Cardiology/World congress of Cardiology 2007. In: Oral Presentation for the Young Investigator Award in Thrombosis.
- AstraZeneca receives action letter from FDA for ExantaTM (ximelagatran).
- Successful outcome of the mutual recognition procedure for ExantaTM (ximelagatran) in Europe. Press release from European Agency for the Evaluation of Medicinal Products (EMEA).
- AstraZeneca Decides to Withdraw ExantaTM (ximelagatran). Press release from AstraZeneca International. (2006) February 15.
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