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European Heart Journal Advance Access originally published online on September 13, 2007
European Heart Journal 2007 28(21):2688-2689; doi:10.1093/eurheartj/ehm386
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2007. For permissions please email: journals.permissions@oxfordjournals.org

Acute chromosomal DNA damage after radiation exposure

Ali Yildiz

Department of Cardiology
Harran University School of Medicine
P.K:112
63100 Sanliurfa
Turkey

Sema Yildiz

Department of Radiology
Harran University School of Medicine
Sanliurfa
Turkey

Recep Demirbag

Department of Cardiology
Harran University School of Medicine
Sanliurfa
Turkey

Remzi Yilmaz

Department of Cardiology
Harran University School of Medicine
Sanliurfa
Turkey

Mustafa Gur

Department of Cardiology
Harran University School of Medicine
Sanliurfa
Turkey

Tel: +90 505 327 42 65 Fax: +90 414 315 11 81 E-mail address: ghcayildiz{at}yahoo.com

We read the article by Andreassi et al.1 dealing with the impact of radiation exposure on acute chromosomal DNA damage in human lymphocytes with great interest. The authors reported significantly increased chromosomal damage in lymphocytes by revealing increased percent of micronucleus in samples of second and 24th hours after radiation exposure in invasive cardiovascular procedures compared to baseline levels. In our opinion, some points of this work are not sufficiently clear.

Authors revealed significantly increased percent of micronucleus in samples of second and 24th hours after the procedure compared to baseline levels in percutaneous coronary intervention, peripheral transluminal angioplasty, and cardiac resynchronization therapy groups, and the discussion of the current report was chiefly based on the influence of radiation exposure on acute chromosomal DNA damage. However, in order to reveal a pathophysiological link between radiation exposure and acute chromosomal DNA damage, the correlation between change in chromosomal DNA damage and magnitude of radiation exposure such as fluoroscopy time, effective dose, or dose-area product would have been assessed.

Percutaneous coronary interventions have been reported to be related with myocardial ischaemia evidenced by post-procedural elevated cardiac enzymes. Myocardial ischaemia has been reported to be a cause of lymphocyte DNA damage as well.2 Evaluating the influence of ischaemia on acute chromosomal DNA damage by analysing the correlation between the magnitude of chromosomal DNA damage and the serum levels of cardiac markers in percutaneous coronary intervention group would aid in excluding a potential cause of acute chromosomal DNA damage.

Finally, but not least importantly, in the present report authors could not find significant change in acute chromosomal DNA damage in coronary angiography group inconsistent with a recent report revealing significantly increased lymphocyte DNA damage in 54 patients undergoing coronary angiography.3 Small sample size of the coronary angiography group (n = 9) in the present report might be the cause of this insignificance.

References

  1. Andreassi MG, Cioppa A, Manfredi S, Palmieri C, Botto N, Picano E. Acute chromosomal DNA damage in human lymphocytes after radiation exposure in invasive cardiovascular procedures. Eur Heart J (2007) June;28. Epub ahead of print.
  2. Demirbag R, Yilmaz R, Gur M, Kocyigit A, Celik H, Guzel S, Selek S. Lymphocyte DNA damage in patients with acute coronary syndrome and its relationship with severity of acute coronary syndrome. Mutat Res (2005) 578:298–307.[Web of Science][Medline]
  3. Demirbag R, Yilmaz R, Kocyigit A, Guzel S. Effect of the coronary angiography on oxidative DNA damage observed in circulating lymphocytes. Angiology (2007) 58:141–147.[Abstract/Free Full Text]

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This Article
Right arrow FREE Full Text (PDF) Freely available
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28/21/2688-a    most recent
ehm386v1
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