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European Heart Journal Advance Access originally published online on February 13, 2007
European Heart Journal 2007 28(6):774-775; doi:10.1093/eurheartj/ehl540
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© The European Society of Cardiology 2007. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org

CD4 + CD25 + regulatory T-cells in acute coronary syndromes

Ali Yildiz

Department of Cardiology
Harran University School of Medicine
P.K.: 112
63100 Sanliurfa
Turkey

Mustafa Gur

Department of Cardiology
Harran University School of Medicine
P.K.: 112
63100 Sanliurfa
Turkey

Tel: +90 505 327 42 65 Fax: +90 414 315 11 81 E-mail address: ghcayildiz{at}yahoo.com

We read with great interest the article by Mor et al.1 dealing with CD4 + CD25 + regulatory T-cells in acute coronary syndromes (ACS). The authors revealed decreased CD4 + CD25+ T-cell count, foxp3, and CTLA-4 and reduced suppressive function of CD4 + CD25+ T-cells on responder CD4 + CD25– T-cells in patients with ACS. They also demonstrated increased sensitivity of CD4 + CD25+ T-cells to oxLDL-mediated depletion in cases with ACS. In our opinion, some points of this work are not sufficiently clear.

In Table 1, percentage of diabetic cases was different among groups of ACS (22%), stable angina pectoris (29%), and controls (7%); however, statistical significance of this difference was not given. In the ‘Discussion’ section, authors state that the number of peripheral CD4 + CD25 + regulatory T-cells has been shown to be reduced in patients with diabetes by citing Kukreja et al.2 Altered suppressive function of CD4 + CD25+ T-cells in patients with diabetes was also reported.3,4 Contrary to these reports, diabetes was not included in the exclusion criteria, and no information was given concerning the adjustment for diabetes despite the fact that the count and functional status of CD4 + CD25+ regulatory T-cells in the study of Mor et al.1 might have been influenced by the inclusion of diabetic cases.

References

  1. Mor A, Luboshits G, Planer D, Keren G, George J. (2006) Altered status of CD4 + CD25+ regulatory T cells in patients with acute coronary syndromes. Eur Heart J 27:2530–2537.[Abstract/Free Full Text]
  2. Kukreja A, Cost G, Marker J, Zhang C, Sun Z, Lin-Su K, Ten S, Sanz M, Exley M, Wilson B, Porcelli S, Maclare N. (2002) Multiple immuno-regulatory defects in type-1 diabetes. J Clin Invest 109:131–140.[CrossRef][Web of Science][Medline]
  3. Lindley S, Dayan CM, Bishop A, Roep BO, Peakman M, Tree TI. (2005) Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes. Diabetes 54:92–99.[Abstract/Free Full Text]
  4. Brusko TM, Wasserfall CH, Clare-Salzler MJ, Schatz DA, Atkinson MA. (2005) Functional defects and the influence of age on the frequency of CD4 + CD25+ T-cells in type 1 diabetes. Diabetes 54:1407–1414.[Abstract/Free Full Text]

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This Article
Right arrow FREE Full Text (PDF) Freely available
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28/6/774-a    most recent
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