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European Heart Journal Advance Access originally published online on April 14, 2008
European Heart Journal 2008 29(11):1472; doi:10.1093/eurheartj/ehn160
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

Mild renal dysfunction associated with incident coronary artery disease in young males (from MELANY Study Investigators)

Ismail Biyik

Department of Cardiology
Usak State Hospital
Ismetpasa caddesi 57/1
Usak 64100
Turkey
Tel: +90 542 417 3209
Fax: +90 276 223 8475
Email: ismailbiyikmd{at}yahoo.com

I read the research report from Pereg et al. in the related issue of European Heart Journal. Some wrong statements changing the meaning of the results of the study drew my attention at the third paragraph on page 201.

(1) They have stated ‘Of note, 31 subjects with CAD were in the fifth quintile (Table 2)’.
According to my opinion, true statement concordant with Table 2 should be such as ‘Of note, 31 subjects with CAD were in the first quintile (Table 2)’.
(2) They have also stated ‘When an age adjustment analysis was performed, we observed a significant and progressive increase in the risk of CAD as the estimated creatinin clearance decreased, and the risk for CAD was found to be significantly higher in the fifth compared with the first quintile (HR = 4.77, 95% confidence interval 3.22–7.06, P < 0.001) (Table 2)’.
According to my opinion, true statement concordant with Table 2 should be such as ‘When an age adjustment analysis was performed, we observed a significant and progressive increase in the risk of CAD as the estimated creatinin clearance decreased, and the risk for CAD was found to be significantly higher in the first compared with the fifth quintile (HR = 4.77, 95% confidence interval 3.22–7.06, P < 0.001) (Table 2)’.
(3) Their another statement is ‘In a multivariable model, adjusted for family history of CAD, blood pressure, cholesterol values, and smoking status, the inverse association between estimated creatinine clerance and the risk for CAD remained, and the increased risk for CAD in the fifth compared with the first quintile persisted (HR = 2.69, 95% confidence interval 1.19–5.72, P < 0.001) (Table 2)’.
According to my opinion, true statement concordant with Table 2 should be such as ‘In a multivariable model, adjusted for family history of CAD, blood pressure, cholesterol values, and smoking status, the inverse association between estimated creatinine clerance and the risk for CAD remained, and the increased risk for CAD in the first compared with the fifth quintile persisted (HR = 2.69, 95% confidence interval 1.19–5.72, P < 0.001) (Table 2)’.

I think that they have confused or overlooked the results of first and fifth groups.

Reference

  1. Pereg D, Tirosh A, Shochat T, Hasdai D. Mild renal dysfunction associated with incident coronary artery disease in young males. Eur Heart J (2008) 29:198–203.[Abstract/Free Full Text]

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This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
29/11/1472    most recent
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