European Heart Journal Advance Access originally published online on October 5, 2007
European Heart Journal 2008 29(2):277; doi:10.1093/eurheartj/ehm439
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Guidelines for the diagnosis and treatment of non-ST segment elevation acute coronary syndromes
Manchester Medical Society
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An issue, which is not addressed by the guidelines, is whether, in the absence of Sgarbossa's criteria, the association of acute coronary syndrome (ACS) type chest pain1 and left bundle branch block (LBBB) falls within the province of non-ST segment elevation ACS (nSTE-ACS) or whether it falls within the province of acute myocardial infarction. Strictly speaking, it is only when Sgarbossa's criteria2 are met that the association of ACS-type chest pain and LBBB should be categorized as ST segment elevation myocardial infarction (STEMI). Conversely, given the fact that, in the absence of Sgarbossa's criteria there is no concordant ST segment deviation, the association of ACS-type chest pain and LBBB should, strictly speaking, be categorized as nSTE-ACS. However, in view of the poor sensitivity of Sgarbossa's criteria for the diagnosis of myocardial infarction3 the current recommendation is that LBBB, irrespective of compliance with Sgrabossa's criteria, should be sufficient justification for thrombolysis provided it is ‘new or presumably new’.4 What is not known is whether LBBB which is non-compliant with Sgarbossa's criteria (i.e. non-ST segment elevation LBBB) is as prevalent in nSTE- ACS as it is in acute myocardial infarction, and whether, in the presence of ACS-type chest pain and non-ST segment elevation LBBB it is possible to distinguish between acute myocardial infarction and nSTE-ACS. These issues should be addressed urgently, so that clinicians confronted with the association of ACS-type chest pain and non-ST segment elevation LBBB should be able to make an informed decision whether to manage the patient along the lines recommended for acute myocardial infarction4 or along the lines specified for nSTE-ACS1.
The absence of a policy statement is even more glaring in the instance of old left bundle branch block (old LBBB), given the fact that, in one study, the proportion of acute myocardial infract (AMI) patients presenting with old LBBB (30/1125) was virtually identical with the proportion of AMI patients presenting with new LBBB (34/1125)5. Conversely, given the fact that as many as 86% of nSTE-ACS patients have unstable angina (UA) rather than enzymatically proven AMI6, allowance for the fact that some patients with old LBBB might fit into the UA category should be reflected in an enrollment policy for nSTE-ACS which explicitly includes bundle branch block (both LBBB and right bundle branch block)6 as opposed to one which does not7.
References
- Bassand J-P, Hamm CW, Ardissino D, Boersma E, Budaj A, Fernandez-Aviles F, Fox K, Hasdai D, Ohman EM, Wallentin L, Wijns W. Guidelines for the diagnosis and treatment of non-ST-segment elevation acute coronary syndromes. Eur Heart J (2007) 28:1598–1660.
[Free Full Text] - Sgarbossa EB, Pinski SL, Barbagelata A, Underwood DA, Gates KB, Topol EJ, Califf RM, Wagner GS. Electrocardiographic diagnosis of evolving acute myocardial infraction in the presence of left bundle branch block. N Engl J Med (1996) 334:481–487.
[Abstract/Free Full Text] - Shlipak MG, Lyons WL, Go AS, Chou TM, Evans T, Browner WS. Should the electrocardiogram be used to guide therapy for patients with left bundle branch block and suspected myocardial infarction? JAMA (1999) 281:714–719.
[Abstract/Free Full Text] - Ambe D, Armstrong PW, Bates ER, Hand M, Hochman JS, Krumholz HM, Kushner FG, Lamas GA, Ornato JP, Pearle DL, Smith SC. ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction. Circulation (2004) 110:588–636.
[Free Full Text] - Gann D, Balachandran PK, Sherif NE, Samet P. Prognostic significance of chronic versus acute bundle branch block in acute myocardial infarction. CHEST (1975) 67:298–303.[CrossRef][Web of Science][Medline]
- Collinson J, Bakhai A, Taneja A, Wang D, Flather MD. Admission ECG predicts long-term outcome in acute coronary syndrome without ST elevation. Quarterly Journal of Medicine (2006) 99:601–607.
[Abstract/Free Full Text] - Lagerqvist B, Husted S, Kontny F, Stahle E, Swahn E, Wallentin L, and the Fast Revascularisation during InStability in Coronary artery disease(FRISC-II) Investigators. Lancet (2006) 368:998–1004.[CrossRef][Medline]
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