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European Heart Journal Advance Access originally published online on February 26, 2008
European Heart Journal 2008 29(7):953-954; doi:10.1093/eurheartj/ehn058
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

Risk of type 2 diabetes mellitus in those with hypertension: reply

David Conen, Paul M. Ridker, Samia Mora, Julie E. Buring and Robert J. Glynn

Brigham and Women's Hospital
900 Commonwealth Avenue East Boston
USA
Email: conend{at}uhbs.ch

We appreciate the detailed description of potential mechanisms that may link blood pressure and type 2 diabetes mellitus. Similar pathophysiological pathways were mentioned in the discussion section of our article1 and have been the focus of our prior work.2–6 We agree that proteomics and gene expression studies could be helpful techniques in this regard. However, the main goal of our work was to assess the relationship between blood pressure and incident type 2 diabetes from a clinical perspective. Quantification of the magnitude of the association of increasing blood pressure levels with risk of developing type 2 diabetes is a helpful message for clinicians in day-to-day practice.

References

  1. Conen D, Ridker PM, Mora S, Buring JE, Glynn RJ. Blood pressure and risk of developing type 2 diabetes mellitus: The Women's Health Study. Eur Heart J (2007) 28:2937–2943.[Abstract/Free Full Text]
  2. Chae CU, Lee RT, Rifai N, Ridker PM. Blood pressure and inflammation in apparently healthy men. Hypertension (2001) 38:399–403.[Abstract/Free Full Text]
  3. Pradhan AD, Manson JE, Rifai N, Buring JE, Ridker PM. C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA (2001) 286:327–334.[Abstract/Free Full Text]
  4. Ridker PM, Buring JE, Cook NR, Rifai N. C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: an 8-year follow-up of 14 719 initially healthy American women. Circulation (2003) 107:391–397.[Abstract/Free Full Text]
  5. Ridker PM, Danielson E, Rifai N, Glynn RJ. Valsartan, blood pressure reduction, and C-reactive protein: primary report of the Val-MARC trial. Hypertension (2006) 48:73–79.[Abstract/Free Full Text]
  6. Sesso HD, Buring JE, Rifai N, Blake GJ, Gaziano JM, Ridker PM. C-reactive protein and the risk of developing hypertension. JAMA (2003) 290:2945–2951.[Abstract/Free Full Text]

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This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
29/7/953    most recent
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