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European Heart Journal 1999 20(16):1182-1190; doi:10.1053/euhj.1998.1481
Copyright © 1999 by the European Society of Cardiology.
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Contemporary management of patients with left ventricular systolic dysfunction. Results from the Study of Patients Intolerant of Converting Enzyme Inhibitors (SPICE) Registry

B.A. Barta,f1, G. Ertlb, P. Heldc, J. Kuchd, A.P. Maggionie, J. McMurrayf, E.L. Michelsong, J.L. Rouleauh, L. Warner Stevensoni, K. Swedbergj, J.B. Youngk, S. Yusufl, M.A. Sellersa, C.B. Grangera, R.M. Califfa and M.A. Pfeffer for the SPICE investigatorsi

a Duke University, Durham, U.S.A.
b II.Med. Universitätsklinik Mannheim/Heidelberg, Heidelberg, Germany
c Astra Hassle, Goteborg, Sweden
d Warsaw University School of Medicine, Warsaw, Poland
e GISSI group, Milano, Italy
f University of Glasgow, Glasgow, U.K.
g Astra Pharmaceuticals LP, Wayne, U.S.A.
h Montreal Heart Institute, Montreal, Canada
i Brigham & Women's Hospital, Boston, U.S.A.
j Goteborg University, Goteborg, Sweden
k Cleveland Clinic, Cleveland, U.S.A.
l McMaster University, Hamilton, Canada

revised December 15, 1998; accepted December 16, 1999 1999

Abstract

Aims The reported prevalence of angiotensin-converting enzyme (ACE) inhibitor use in patients with heart failure varies considerably. Recent reports suggest that many patients who could benefit from such therapy are not receiving ACE inhibitors. The Study of Patients Intolerant of Converting Enzyme Inhibitors (SPICE) Registry was established to understand better the demographics, characteristics, and contemporary use of ACE inhibitors in an international registry.

Methods and Results Between August 1996 and April 1997, each of 105 study centres from eight countries in North America and Europe was invited to review retrospectively the medical records of 100 consecutive patients with left ventricular ejection fractions ≤35%. The median age of the 9580 Registry patients was 66 years, 26% were women, the median ejection fraction was 27%, and the primary aetiology of left ventricular dysfunction was ischaemic (63%). Eighty percent of patients were receiving ACE inhibitors. The most common reason for non-use of ACE inhibitors was intolerance (9%).

Conclusion The SPICE Registry provides a contemporary description of the demographics and management of patients with documented left ventricular systolic dysfunction. The contemporary use of ACE inhibitors (80%) appears to be higher than previously reported and the main reason for non-use is perceived intolerance (9%).

Key Words: Heart failure, ACE inhibitor, management, medication usage

f1 Correspondence: Bradley A. Bart, MD, Assistant Professor of Medicine, Division of Cardiology, Hennepin County Medical Center, 865A, 701 Park Avenue South, Minneapolis, Minnesota 55415, U.S.A.

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