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European Heart Journal 1999 20(20):1493-1502; doi:10.1053/euhj.1999.1519
Copyright © 1999 by the European Society of Cardiology.
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D-dimers in relation to the severity of arteriosclerosis in patients with stable angina pectoris after myocardial infarction

M.-C. Tatarua,f1, J. Heinrichb, R. Junkerc,d, H. Schultec, A. von Eckardsteinc, G. Assmannc,d and E. Koehlere

a Department of Cardiology, Heart-Center, Bad Neustadt
b Hospital Solingen, Solingen
c Institute of Arteriosclosis Research, University of Muenster, Muenster
d Institute of Clinical Chemistry and Laboratory Medicine, University of Muenster, Muenster
e Hospital Meiningen, Meiningen, Germany

revised January 15, 1999; accepted January 20, 1999

Abstract

Background Plasma concentrations of D-dimers show the extent of intravascular fibrinolysis of cross-linked fibrin. Higher concentrations of D-dimers are found in the plasma of arteriosclerosis patients with increased fibrin metabolism. The present study was performed in order to investigate whether there is a relationship between the severity of arteriosclerosis and fibrinolytic activity indicated by plasma levels of D-dimer.

Methods The study populations consisted of 1112 men and 299 women with stable angina pectoris, on average 36±5·6 days after a myocardial infarction, as well as 326 men and 138 women with no clinical signs of cardiovascular disease. In addition to cardiological and angiological examinations, the lipid status and levels of fibrinogen, plasma viscosity, F 1+2, plasminogen, plasminogen activator inhibitor-1, D-dimer, and C-reactive protein of the participants were determined.

Results The plasma concentration of D-dimers increases with age, both in the group with coronary artery disease and in the control group, with the female gender showing consistently higher concentrations in both groups. D-dimers correlate with other parameters of the lipid and coagulation systems, which explains 32·0% and 39·2% of the variance in D-dimer values in men and women, respectively. A significant increase in the level of D-dimers can be found in participants with generalized arteriosclerosis, with a left ventricular ejection fraction ≤40% as well as those with left-ventricular aneurysm.

Conclusion This study indicates that there is increased fibrinolytic activity in patients with severe arteriosclerosis. This finding gives further support to the hypothesis that D-dimer concentration is dependent on the amount of fibrin associated with arteriosclerotic thrombi. However, because of the low specificity and wide overlap of D-dimer values between patients and controls, enhanced D-dimer values are of limited relevance above and beyond other lipid metabolism risk indicators for coronary artery disease or coronary artery disease and peripheral arterial occlusive disease.

Key Words: D-dimer, age-dependency, myocardial infarction, fibrinolysis, left ventricular dysfunction.

f1 Correspondence : Mira-Christine Tataru, MD, Heart-Center, Department of Cardiology, Salzburger Leite 1, D-97616 Bad Neustadt, Germany.

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