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European Heart Journal 1999 20(4):285-292; doi:10.1053/euhj.1998.1195
Copyright © 1999 by the European Society of Cardiology.
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Coronary blood flow reserve and wall motion recovery in patients undergoing angioplasty for myocardial infarction

E. Teigera, J. Garota, E. Aptecara, P. Bosioa, J. Woscoboinika, J.M. Pernesa, P. Guereta, M. Kernb, Dubois-RandéJ.-L. a,f1 and P. Dupouya

a Service des Explorations Fonctionnelles, Fédération de Cardiologie et Institut National de la Santé et de la Recherche Médicale, U400, Service de Médecine Nucléaire, France
b St Louis University, St Louis, MO, U.S.A.

revised June 29, 1998; accepted July 3, 1998

Abstract

Aims The aim of this study was to evaluate the relationship between coronary flow reserve and the recovery of wall motion contractility in patients with recent myocardial infarction.

Methods and Results Nineteen patients (55±8 years) undergoing balloon angioplasty for recent myocardial infarction were studied. After angioplasty, coronary flow reserve was lower in the infarct-related artery than in a reference artery, 2·2±0·6 and 2·8±0·7, respectively,P<0·05. There was no immediate correlation between coronary blood flow reserve measured after angioplasty and wall motion index. There was a negative correlation between coronary flow reserve and the number of necrotic segments (r=–0·43;P0·006). At the 4 month control angiogram, there was a significant increase in both left ventricular ejection fraction (59±14% vs 51±13%;P<0·05) and wall motion index (–0·63±1·2 vs –1·94±0·9 units SD,P=0·005). In patients in whom wall motion improved (>1 unit SD), the immediate coronary flow reserve was higher (P<0·05) than in patients without improved wall motion. In this group, the increase in wall motion index was correlated to the coronary blood flow reserve (r=0·55;P<0·02).

Conclusion These data show that after myocardial infarction, coronary flow reserve is associated with myocardial viability.

Key Words: Myocardial infarction • occlusion • coronary flow reserve • wall motion contractility

f1 Correspondence: Dr Dubois-Randé, Service de Cardiologie, Hôpital Henri Mondor, 94010, Créteil, France.

Topol, EJ

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