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European Heart Journal 2000 21(1):58-65; doi:10.1053/euhj.1999.1733
Copyright © 2000 by the European Society of Cardiology.
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Signal-averaged electrocardiogram in patients with arrhythmogenic right ventricular cardiomyopathy and ventricular arrhythmias

A Navaa,f1, A.F Folinoa, B Baucea, P Turrinia, G.F Bujaa, L Dalientoa and G Thieneb

a Departments of Cardiology, University of Padua Medical School, Padua, Italy
b Cardiovascular Pathology, University of Padua Medical School, Padua, Italy

revised March 18, 1999; accepted March 19, 1999

Abstract

Objective The aim of the study was to assess the prevalence, sensitivity, specificity and predictive value of the signal-averaged ECG in patients with arrhythmogenic right ventricular cardiomyopathy and different forms of ventricular arrhythmias.

Methods The signal averaged ECG in 138 patients and 146 healthy subjects (control group), using a three bandpass filter system (25–250, 40–250, 80–250 Hz), was considered abnormal when at least two parameters were abnormal at each filter setting. Patients were divided into three groups according to the extent of the right ventricular enlargement (mild, moderate, extensive), and into five groups according to the type of ventricular arrhythmia.

Results The signal averaged ECG was abnormal in 57% of the patients and in 4% of the healthy subjects. The sensitivity was 57%, specificity 95% and positive predictive value 92%. The signal averaged ECG was abnormal in 94·4% of patients with the extensive form of the disease, in 77·7% of patients with the moderate form and in 31·8% of patients with the minor form, demonstrating good correlation with the extent of the disease. According to the type of ventricular arrhythmia, a higher correlation was found between signal averaged ECG abnormality and sustained ventricular tachycardia with superior axis (94·4%,P <0·02); the correlation for the other arrhythmias varied from 16·6% to 55·8%.

Conclusion There is a closer correlation between the signal averaged ECG and extent of disease than with the presence of ventricular arrhythmias. The signal averaged ECG is not helpful in diagnosing minor forms of the disease, but since it is a non-invasive method, it may be useful in evaluating progression of the disease.

Key Words: Signal-averaged electrocardiogram, arrhythmogenic right ventricular cardiomyopathy, ventricular arrhythmias

f1 Correspondence: Andrea Nava, MD, c/o Associazione Ricerche Cardiopatie Aritmiche (A.R.C.A.), Via Gabelli, 86, 35100, Padua, Italy.

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