European Heart Journal

European Heart Journal 2000 21(10):823-831; doi:10.1053/euhj.1999.1993
Copyright © 2000 by the European Society of Cardiology.

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Multicentre randomized trial comparing transport to primary angioplasty vs immediate thrombolysis vs combined strategy for patients with acute myocardial infarction presenting to a community hospital without a catheterization laboratory. The PRAGUE Study

P. Widimsk^a,f1, L. Groch^a, M. Zelízko^a, M. Aschermann^a, F. Bedná^a and H. Suryapranata^b

^a Cardiocenter, University Hospital, Vinohrady, Prague, Czech Republic
^b Hospital De Weezenlanden, Zwolle, The Netherlands

revised October 4, 1999; accepted October 6, 1999

Abstract

Background Primary coronary angioplasty is an effective reperfusion strategy in acute myocardial infarction. However, its availability is limited, and transporting patients to an angioplasty centre in the acute phase of myocardial infarction has not yet been proved safe.

Methods The PRAGUE study (PRimary Angioplasty in patients transferred from General community hospitals to specialized PTCA Units with or without Emergency thrombolysis) compared three reperfusion strategies in patients with acute myocardial infarction, presenting within 6h of symptom onset at community hospitals without a catheterization laboratory: group A—thrombolytic therapy in community hospitals (n=99), group B—thrombolytic therapy during transportation to angioplasty (n=100), group C—immediate transportation for primary angioplasty without pre-treatment with thrombolysis (n=101).

Results No complications occurred during transportation in group C. Two ventricular fibrillations occurred during transportation in group B. Median admission–reperfusion time in transported patients (group B 106min, group C 96min) compared favourably with the anticipated >90min in group A. The combined primary end-point (death/reinfarction/stroke at 30 days) was less frequent in group C (8%) compared to groups B (15%) and A (23%, P<0·02). The incidence of reinfarction was markedly reduced by transport to primary angioplasty (1% in group C vs 7% in group B vs 10% in group A,P <0·03).

Conclusions Transferring patients from community hospitals to a tertiary angioplasty centre in the acute phase of myocardial infarction is feasible and safe. This strategy is associated with a significant reduction in the incidence of reinfarction and the combined clinical end-point of death/reinfarction/stroke at 30 days when compared to standard thrombolytic therapy at the community hospital.

Key Words: acute myocardial infarction, reperfusion, thrombolysis, transport, primary coronary angioplasty

^f1 Correspondence: Petr Widimský, MD, PhD, FESC, Cardiocenter Vinohrady, robárova 50, 100 34 Prague 10, Czech Republic.

References

1. Lancet. 1986;1:397–402[CrossRef][Medline]
2. Barbagelata NA, Granger CB, Oqueli E. TIMI grade 3 flow and reocclusion after intravenous thrombolytic therapy: a pooled analysis. Am Heart J. 1997;133:273–282[CrossRef][Web of Science][Medline]
3. Gulba DC, Tanswell P, Dechend R. Sixty-minute alteplase protocol: a new accelerated recombinant tissue-type plasminogen activator regimen for thrombolysis in acute myocardial infarction. J Am Coll Cardiol. 1997;30:1611–1617[Abstract]
4. Meyer J, Merx W, Dorr R, Lambertz H, Bethge C, Effert S. Succesful treatment of acute myocardial infarction shock by combined percutaneous transluminal coronary recanalization and percutaneous transluminal coronary angioplasty. Am Heart J. 1982;103:132–138[CrossRef][Web of Science][Medline]
5. Hartzler GO, Rutherford BD, McConnay DR. Percutaneous transluminal coronary angioplasty with and without thrombolytic therapy for treatment of acute myocardial infarction. Am Heart J. 1983;106:965–973[CrossRef][Web of Science][Medline]
6. Zijlstra F, de Boer MJ, Hoorntje JCA, Reiffers S, Reiber JHC, Suryapranata H. A comparison of immediate coronary angioplasty with intravenous streptokinase in acute myocardial infarction. N Engl J Med. 1993;328:680–684[Abstract/Free Full Text]
7. Grines CL, Browne KF, Marco J. A comparison of immediate angioplasty with thrombolytic therapy for acute myocardial infarction. N Engl J Med. 1993;328:673–679[Abstract/Free Full Text]
8. Gibbons RJ, Holmes DR, Reeder GS, Bailey KR, Hopfenspirger MR, Gersh BJ. Immediate angioplasty compared with the administration of a thrombolytic agent followed by conservative treatment for myocardial infarction. N Engl J Med. 1993;328:685–691[Abstract/Free Full Text]
9. N Engl J Med. 1997;336:1621–1628[Abstract/Free Full Text]
10. Stone GW, Grines CL, O'Neill WW. Primary coronary angioplasty versus thrombolysis. N Engl J Med. 1997;337:1168–1169[Free Full Text]
11. Christian TF, O'Keefe JH, DeWood MA. Intercenter variability in outcome for patients treated with direct coronary angioplasty during acute myocardial infarction. Am Heart J. 1998;135:310–317[CrossRef][Web of Science][Medline]
12. Zijlstra F, Beukema WP, van't Hof AWJ. A randomized comparison of primary coronary angioplasty with thrombolytic therapy in low risk patients with an acute myocardial infarction. J Am Coll Cardiol. 1997;29:908–912[Abstract]
13. Brown DL. An analysis of percutaneous transluminal coronary angioplasty performed in California in 1995. J Am Coll Cardiol. 1998;32:
14. Weaver DW, Cerqueira M, Hallstrom AP. Pre-hospital-initiated vs. hospital-initiated thrombolytic therapy. The myocardial infarction triage and intervention trial. JAMA. 1993;270:1211–1216[Abstract/Free Full Text]
15. Rawles JM. Quantification of the benefit from earlier thrombolytic therapy: the Grampion Regional Anistreplase Trial (GREAT). J Am Coll Cardiol. 1997;30:1181–1186[Abstract]
16. van't Hof AWJ, Liem A, Suryapranata H, Hoorntje JCA, de Boer MJ, Zijlstra F. Clinical presentation and outcome of patients with early, intermediate and late reperfusion therapy by primary coronary angioplasty for acute myocardial infarction. Eur Heart J. 1998;19:118–123[Abstract/Free Full Text]
17. Liem AL, van't Hof AWJ, Hoorntje JCA, de Boer MJ, Suryapranata H, Zijlstra F. Influence of treatment delay on infarct size and clinical outcome in patients with acute myocardial infarction treated with primary angioplasty. J Am Coll Cardiol. 1998;32:629–633[Abstract/Free Full Text]
18. Zijlstra F, van't Hof AWJ, Liem AL, Hoorntje JCA, Suryapranata H, de Boer MJ. Transferring patients for primary angioplasty: a retrospective analysis of 104 selected high risk patients with acute myocardial infarction. Heart. 1997;78:333–336[Abstract/Free Full Text]
19. Barron HV, Malacreda R, Weaver WD. Use of helicopter transportation in acute myocardial infarction in the United States. J Am Coll Cardiol. 1998;32:
20. Vermeer F, Werter C, van de Berg E. Safety and feasibility of rescue PTCA or primary PTCA in patients with acute myocardial infarction admitted to a hospital without PTCA facilities. J Am Coll Cardiol. 1997;29:390A
21. Budínský T, Widimský P, Dvoák J, Lisa L. Transport of patients with acute myocardial infarction to coronary angioplasty. Cor Vasa. 1998;40:368–369
22. Willerson JT, Watson JT, Hutton I, Templeton GH, Fixler DE. Reduced myocardial reflow and increased coronary vascular resistence following prolonged myocardial ischemia in the dog. Circ Res. 1975;36:771–781[Abstract/Free Full Text]
23. Reimer KA, Lowe JE, Rasmussen MM, Jennings RB. The wavefront phenomenon of ischemic cell death. 1. Myocardial infarct size vs. duration of coronary occlusion in dogs. Circulation. 1977;56:786–794[Abstract/Free Full Text]
24. Hasche ET, Fernandes C, Freedman SB, Jeremy RW. Relation between ischemia time, infarct size, and left ventricular function in humans. Circulation. 1995;92:710–719[Abstract/Free Full Text]
25. Raitt MH, Maynard C, Wagner GS, Cerqueirra MD, Selvester RH, Weaver WD. Relation between symptom duration before thrombolytic therapy and final myocardial infarct size. Circulation. 1996;93:48–53[Abstract/Free Full Text]
26. Brodie BR, Stuckey TD, Wall TC. Importance of time to reperfusion for 30-day and late survival and recovery of left ventricular function after primary angioplasty for acute myocardial infarction. J Am Coll Cardiol. 1998;32:1312–1319[Abstract/Free Full Text]
27. Stone GW, O'Keefe J, Brodie BR, O'Neill WW, Grines CL. Lack of relationship between the time to reperfusion and short term mortality after primary infarct angioplasty. J Am Coll Cardiol. 1998;32:
28. French WJ, Sada MJ. Benefit of primary angioplasty in patients presenting late with ST segment elevation and acute myocardial infarction. J Am Coll Cardiol. 1998;32:
29. J Am Coll Cardiol. 1996;28:1328–1428[CrossRef][Web of Science][Medline]
30. Lee KL, Woodlief LH, Topol EJ. Predictors of 30-day mortality in the era of reperfusion for acute myocardial infarction. Results from an international trial of 41021 patients. Circulation. 1995;91:1659–1668[Abstract/Free Full Text]
31. Erbel R, Pop T, Henrichs KJ, Rupprecht HJ, Steuernagel C, Meyer J. Percutaneous transluminal coronary angioplasty after thrombolytic therapy: a prospective controlled randomized trial. J Am Coll Cardiol. 1986;8:485–495[Abstract]
32. Simoons ML, Arnold AER, Betriu A. Thrombolysis with tissue plasminogen activator in acute myocardial infarction: no additional benefit from immediate percutaneous coronary angioplasty. Lancet. 1988;I:197–203
33. N Engl J Med. 1989;320:618–627[Abstract]
34. Br Med J. 1991;302:555[Abstract/Free Full Text]

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				C. J. Terkelsen, J. F. Lassen, B. L. Norgaard, J. C. Gerdes, S. H. Poulsen, K. Bendix, J. P. Ankersen, L. B.-H. Gotzsche, F. K. Romer, T. T. Nielsen, et al. Reduction of treatment delay in patients with ST-elevation myocardial infarction: impact of pre-hospital diagnosis and direct referral to primary percutanous coronary intervention Eur. Heart J., April 2, 2005; 26(8): 770 - 777. [Abstract] [Full Text] [PDF]

				Authors/Task Force Members, S. Silber, P. Albertsson, F. F. Aviles, P. G. Camici, A. Colombo, C. Hamm, E. Jorgensen, J. Marco, J.-E. Nordrehaug, et al. Guidelines for Percutaneous Coronary Interventions: The Task Force for Percutaneous Coronary Interventions of the European Society of Cardiology Eur. Heart J., April 2, 2005; 26(8): 804 - 847. [Full Text] [PDF]

				S. S. Rathore, A. J. Epstein, K. G. M. Volpp, and H. M. Krumholz Regionalization of Care for Acute Coronary Syndromes: More Evidence Is Needed JAMA, March 16, 2005; 293(11): 1383 - 1387. [Full Text] [PDF]

				B. J. Gersh, G. W. Stone, H. D. White, and D. R. Holmes Jr Pharmacological Facilitation of Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction: Is the Slope of the Curve the Shape of the Future? JAMA, February 23, 2005; 293(8): 979 - 986. [Abstract] [Full Text] [PDF]

				H. C. Herrmann Transfer for Primary Angioplasty: The Importance of Time Circulation, February 15, 2005; 111(6): 718 - 720. [Full Text] [PDF]

				B. K. Nallamothu, E. R. Bates, J. Herrin, Y. Wang, E. H. Bradley, H. M. Krumholz, and for the NRMI Investigators Times to Treatment in Transfer Patients Undergoing Primary Percutaneous Coronary Intervention in the United States: National Registry of Myocardial Infarction (NRMI)-3/4 Analysis Circulation, February 15, 2005; 111(6): 761 - 767. [Abstract] [Full Text] [PDF]

				S D Kristensen, H R Andersen, L Thuesen, L R Krusell, H E Botker, J F Lassen, and T T Nielsen Should patients with acute ST elevation MI be transferred for primary PCI? Heart, November 1, 2004; 90(11): 1358 - 1363. [Full Text] [PDF]

				J. M. Brophy and P. Bogaty Primary Angioplasty and Thrombolysis Are Both Reasonable Options in Acute Myocardial Infarction Ann Intern Med, August 17, 2004; 141(4): 292 - 297. [Abstract] [Full Text] [PDF]

				E. C. Keeley and C. L. Grines Primary Percutaneous Coronary Intervention for Every Patient with ST-Segment Elevation Myocardial Infarction: What Stands in the Way? Ann Intern Med, August 17, 2004; 141(4): 298 - 304. [Abstract] [Full Text] [PDF]

				Writing Committee Members, E. M. Antman, D. T. Anbe, P. W. Armstrong, E. R. Bates, L. A. Green, M. Hand, J. S. Hochman, H. M. Krumholz, F. G. Kushner, et al. ACC/AHA guidelines for the management of patients with ST-Elevation myocardial infarction--executive summary: A report of the American College of Cardiology/American Heart Association Task Force on practice guidelines (writing committee to revise the 1999 guidelines for the management of patients with acute myocardial infarction) J. Am. Coll. Cardiol., August 4, 2004; 44(3): 671 - 719. [Full Text] [PDF]

				E. M. Antman, D. T. Anbe, P. W. Armstrong, E. R. Bates, L. A. Green, M. Hand, J. S. Hochman, H. M. Krumholz, F. G. Kushner, G. A. Lamas, et al. ACC/AHA Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction--Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 1999 Guidelines for the Management of Patients With Acute Myocardial Infarction) Circulation, August 3, 2004; 110(5): 588 - 636. [Full Text] [PDF]

				I. A. Khan Initial Therapy for Acute Myocardial Infarction in the Real World Chest, August 1, 2004; 126(2): 331 - 333. [Full Text] [PDF]

				A. G. C. Sutton, P. G. Campbell, R. Graham, D. J. A. Price, J. C. Gray, E. D. Grech, J. A. Hall, A. A. Harcombe, R. A. Wright, R. H. Smith, et al. A randomized trial of rescue angioplasty versus a conservative approach for failed fibrinolysis in ST-segment elevation myocardial infarction: The Middlesbrough Early Revascularization to Limit INfarction (MERLIN) trial J. Am. Coll. Cardiol., July 21, 2004; 44(2): 287 - 296. [Abstract] [Full Text] [PDF]

				C. L. Grines and W. W. O'Neill Rescue angioplasty: Does the concept need to be rescued? J. Am. Coll. Cardiol., July 21, 2004; 44(2): 297 - 299. [Full Text] [PDF]

				G. Montalescot, M. Borentain, L. Payot, J. P. Collet, and D. Thomas Early vs Late Administration of Glycoprotein IIb/IIIa Inhibitors in Primary Percutaneous Coronary Intervention of Acute ST-Segment Elevation Myocardial Infarction: A Meta-analysis JAMA, July 21, 2004; 292(3): 362 - 366. [Abstract] [Full Text] [PDF]

				M. Togni, F. Balmer, D. Pfiffner, W. Maier, A. M Zeiher, B. Meier, and on behalf of the Working Group Interventional Card Percutaneous coronary interventions in Europe 1992-2001 Eur. Heart J., July 2, 2004; 25(14): 1208 - 1213. [Abstract] [Full Text] [PDF]

				R. E. Waters II, K. P. Singh, M. T. Roe, M. Lotfi, M. H. Sketch Jr, K. W. Mahaffey, L. K. Newby, J. H. Alexander, R. A. Harrington, R. M. Califf, et al. Rationale and strategies for implementing community-based transfer protocols for primary percutaneous coronary intervention for acute ST-segment elevation myocardial infarction J. Am. Coll. Cardiol., June 16, 2004; 43(12): 2153 - 2159. [Abstract] [Full Text] [PDF]

				G Montalescot, H R Andersen, D Antoniucci, A Betriu, M J de Boer, L Grip, F J Neumann, and M T Rothman Recommendations on percutaneous coronary intervention for the reperfusion of acute ST elevation myocardial infarction Heart, June 1, 2004; 90(6): e37 - e37. [Abstract] [Full Text] [PDF]

				E. M. Antman and F. Van de Werf Pharmacoinvasive Therapy: The Future of Treatment for ST-Elevation Myocardial Infarction Circulation, June 1, 2004; 109(21): 2480 - 2486. [Full Text] [PDF]

				A. Kastrati, J. Mehilli, K. Schlotterbeck, F. Dotzer, J. Dirschinger, C. Schmitt, S. G. Nekolla, M. Seyfarth, S. Martinoff, C. Markwardt, et al. Early Administration of Reteplase Plus Abciximab vs Abciximab Alone in Patients With Acute Myocardial Infarction Referred for Percutaneous Coronary Intervention: A Randomized Controlled Trial JAMA, February 25, 2004; 291(8): 947 - 954. [Abstract] [Full Text] [PDF]

				E. C. Keeley and C. L. Grines Primary Coronary Intervention for Acute Myocardial Infarction JAMA, February 11, 2004; 291(6): 736 - 739. [Full Text] [PDF]

				P. G. Steg, E. Bonnefoy, S. Chabaud, F. Lapostolle, P.-Y. Dubien, P. Cristofini, A. Leizorovicz, P. Touboul, and for the Comparison of Angioplasty and Prehospital Impact of Time to Treatment on Mortality After Prehospital Fibrinolysis or Primary Angioplasty: Data From the CAPTIM Randomized Clinical Trial Circulation, December 9, 2003; 108(23): 2851 - 2856. [Abstract] [Full Text] [PDF]

				K. S. Channer, P. W. Armstrong, E. M. Antman, A. G. Zaman, H. R. Andersen, and T. T. Nielsen Coronary Angioplasty versus Fibrinolytic Therapy in Acute Myocardial Infarction N. Engl. J. Med., November 27, 2003; 349(22): 2167 - 2169. [Full Text] [PDF]

				M. R. Le May, R. F. Davies, M. Labinaz, H. Sherrard, J.-F. Marquis, L. A. Laramee, E. R. O'Brien, W. L. Williams, R. S. Beanlands, G. Nichol, et al. Hospitalization Costs of Primary Stenting Versus Thrombolysis in Acute Myocardial Infarction: Cost Analysis of the Canadian STAT Study Circulation, November 25, 2003; 108(21): 2624 - 2630. [Abstract] [Full Text] [PDF]

				M. Dalby, A. Bouzamondo, P. Lechat, and G. Montalescot Transfer for Primary Angioplasty Versus Immediate Thrombolysis in Acute Myocardial Infarction: A Meta-Analysis Circulation, October 14, 2003; 108(15): 1809 - 1814. [Abstract] [Full Text] [PDF]

				B. Scheller, B. Hennen, B. Hammer, J. Walle, C. Hofer, V. Hilpert, H. Winter, G. Nickenig, M. Bohm, and SIAM III Study Group Beneficial effects of immediate stenting after thrombolysis in acute myocardial infarction J. Am. Coll. Cardiol., August 20, 2003; 42(4): 634 - 641. [Abstract] [Full Text] [PDF]

				R. G. McKay Evolving strategies in the treatment of acute myocardial infarction in the community hospital setting J. Am. Coll. Cardiol., August 20, 2003; 42(4): 642 - 645. [Full Text] [PDF]

				M. K. Natarajan and S. Yusuf Primary angioplasty for ST-segment elevation myocardial infarction: Ready for prime time? Can. Med. Assoc. J., July 8, 2003; 169(1): 32 - 35. [Full Text] [PDF]

				W. A. Ghali, C. R. Donaldson, M. L. Knudtson, S. J. Lewis, C. J. Maxwell, and J. V. Tu Rising to the challenge: transforming the treatment of ST-segment elevation myocardial infarction Can. Med. Assoc. J., July 8, 2003; 169(1): 35 - 37. [Full Text] [PDF]

				E. Buiatti, A. Barchielli, N. Marchionni, D. Balzi, N. Carrabba, S. Valente, I. Olivotto, C. Landini, M. Filice, M. Torri, et al. Determinants of treatment strategies and survival in acute myocardial infarction: a population-based study in the Florence district, Italy: Results of the acute myocardial infarction Florence registry (AMI-Florence), Eur. Heart J., July 1, 2003; 24(13): 1195 - 1203. [Abstract] [Full Text] [PDF]

				C. L. Grines, P. Serruys, and W. W. O'Neill Fibrinolytic Therapy: Is It A Treatment of the Past? Circulation, May 27, 2003; 107(20): 2538 - 2542. [Full Text] [PDF]

				E. J. Topol and D. J. Kereiakes Regionalization of Care for Acute Ischemic Heart Disease: A Call for Specialized Centers Circulation, March 25, 2003; 107(11): 1463 - 1466. [Full Text] [PDF]

				C. L. Grines Reply J. Am. Coll. Cardiol., February 5, 2003; 41(3): 518 - 519. [Full Text] [PDF]

				F Zijlstra Angioplasty vs thrombolysis for acute myocardial infarction: a quantitative overview of the effects of interhospital transportation Eur. Heart J., January 1, 2003; 24(1): 21 - 23. [Full Text] [PDF]

				P. Widimsky, T. Budesinsky, D. Vorac, L. Groch, M. Zelizko, M. Aschermann, M. Branny, J. St'asek, P. Formanek, and on behalf of the 'PRAGUE' Study Group Investigator Long distance transport for primary angioplasty vs immediate thrombolysis in acute myocardial infarction: Final results of the randomized national multicentre trial--PRAGUE-2 Eur. Heart J., January 1, 2003; 24(1): 94 - 104. [Abstract] [Full Text] [PDF]

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