Copyright © 2000 by the European Society of Cardiology.
Diagnosing syncope in clinical practice. Implementation of a simplified diagnostic algorithm in a multicentre prospective trialthe OESIL 2 Study (Osservatorio Epidemiologico della Sincope nel Lazio)
Received June 15, 1999; accepted August 25, 1999
Abstract
Background In some patients with syncope health care is inappropriate and ineffective. In a recent observational investigation in community hospitals of the Lazio region of Italy (the OESIL study) 54·4% of patients admitted with syncope from the emergency room were discharged without a conclusive diagnosis.
Aim of the Study A simplified two-step diagnostic algorithm was developed and prospectively implemented in nine community hospitals of the Lazio region of Italy in order to improve the diagnostic performance of clinicians, thereby reducing the number of undiagnosed patients.
Study Population The study population included 195 consecutive patients (85 males and 110 females, mean age 62·5 years, range 1395 years) presenting with a syncopal spell at the emergency room of one of the nine participating hospitals in a 2-month period.
Results The systematic implementation of the proposed diagnostic algorithm resulted in a striking reduction of undiagnosed cases. The percentage of patients discharged without a conclusive diagnosis decreased from 54·4% to 17·5%. Neurally mediated syncope was diagnosed in 35·2% of cases, cardiac syncope in 20·9% and neurological syncope in 13·8%.
Conclusions The use of specific, simplified diagnostic guidelines and algorithms results in an improvement of overall clinical performance. However, the development of such decision-making aids should carefully consider the local circumstances of daily clinical practice.
Key Words: Syncope, diagnostic guidelines
f1 Correspondence: Dott. Fabrizio Ammirati, Dipartimento delle Malattie del Cuore, Ospedale S. Filippo Neri, Via Attilio Friggeri, 95, 00136, Rome, Italy.
References
- Branch WT Jr. Approach to syncope. J Gen Intern Med. 1986;1:4958[ISI][Medline]
- Manolis AS, Linzer M, Salem D, Estes NAM III. Syncope: current diagnostic evaluation and management. Ann Int Med. 1990;112:850863[ISI][Medline]
- Kapoor WN. Evaluation and management of patients with syncope. JAMA. 1992;268:25532560[Abstract]
- Kapoor WN. Work-up and management of patients with syncope. Med Clin North Am. 1995;79:11531170[ISI][Medline]
- Olshansky B. Syncope: overview and approach to management. Grubb BP, Olshansky B. Syncope: mechanisms and management. Armonk: Futura Publishing; 1998. p. 1571
- Kapoor WN. An overview of the evaluation and management of syncope. Grubb BP, Olshansky B. Syncope: mechanisms and management. New York: Futura Publishing; 1998. p. 113
- Day SC, Cook EF, Funkenstein H, Goldman L. Evaluation and outcome of emergency room patients with transient loss of consciousness. Am J Med. 1982;73:1523[CrossRef][ISI][Medline]
- Eagle KA, Black HR, Cook EF, Goldman L. Evaluation and prognostic classification of patients with syncope. Am J Med. 1985;79:455460[CrossRef][ISI][Medline]
- Alboni P, Raviele A, Vecchio C. Orientamenti sulla valutazione diagnostica dei pazienti con sincope. G Ital Cardiol. 1995;25:937948[Medline]
- Linzer M, Yang EH, Estes NAM III, Wang P, Vorperian V, Kapoor WN. Diagnosing syncope. Part 1: value of history, physical examination and electrocardiography. Ann Intern Med. 1997;126:989996
[Abstract/Free Full Text] - Ammirati F, Colivicchi F, Minardi G. Hospital management of syncope: the OESIL study (Osservatorio Epidemiologico della Sincope nel Lazio). G Ital Cardiol. 1999;29:533539[Medline]
- Lomas J. Words without action?: the production, dissemination and impact of consensus recommendations. Annu Rev Public Health. 1991;12:4165[CrossRef][ISI][Medline]
- Haynes RB. Some problems in applying evidence in clinical practice. Ann NY Acad Sci. 1993;703:210214[Abstract]
- Bergman DA. Evidence-based guidelines and critical pathways for quality improvement. Pediatrics. 1999;103:225232
- Linzer M, Yang EH, Estes NAM III, Wang P, Vorperian V, Kapoor WN. Diagnosing syncope. Part 2: unexplained syncope. Ann Intern Med. 1997;127:7686
[Abstract/Free Full Text] - Martin GJ, Adams SL, Martin HG, Mathews J, Zull D, Scanlon PJ. Prospective evaluation of syncope. Ann Emerg Med. 1984;13:499504[CrossRef][ISI][Medline]
- Recchia B, Barzilai B. Echocardiography in the evaluation of patients with syncope. J Gen Intern Med. 1995;10:649655[ISI][Medline]
- Ammirati F, Colivicchi F, Biffi A, Magris B, Pandozi C, Santini M. Head-up tilt testing potentiated with low-dose sublingual isosorbide dinitrate: a simplified time-saving approach for the evaluation of unexplained syncope. Am Heart J. 1998;135:671676[CrossRef][ISI][Medline]
- Steiberg EP. The importance of performance evaluation in implementation of the Dialysis Outcomes Quality Initiative Guidelines. Adv Ren Replace Ther. 1999;6:3641[ISI][Medline]
- Shaneyfelt TM, Mayo-Smith MF, Rothwangl J. Are guidelines following guidelines? The methodological quality of clinical practice guidelines in the peer-reviewed medical literature. JAMA. 1999;281:19001905
[Abstract/Free Full Text]
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