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European Heart Journal 2000 21(18):1555-1556; doi:10.1053/euhj.2000.2073
Copyright © 2000 by the European Society of Cardiology.
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Letters to the Editor

Cholesterol reduction, statins and the cytochrome P-450 system

J.R. Cockcrofta and I.B. Wilkinsonb

a Department of Cardiology, Wales Heart Research Institute, University Hospital, Heath Park, Cardiff, U.K
b Clinical Pharmacology Unit, Western General Hospital, Edinburgh, U.K

References

  1. Horsmans Y. Differential metabolism of statins: importance in drug-drug interactions. Eur Heart J Supplements. 1999;1:T7–T12
  2. Li Wan Po A, Zhang WY. What lessons can be learnt from the withdrawal of mebefradil from the market. Lancet. 1998;351:1829–1830[CrossRef][ISI][Medline]
  3. Sutton D, Butler AM, Nadin L, Murray M. Role of CYP3A4 in human hepatic diltiazem N-demethylation: Inhibition of CYP3A4 activity by oxidised diltiazem metabolites. J Pharmacol Exp Ther. 1997;282:294–3000[Abstract/Free Full Text]
  4. Chen ZM, Peto R, Collins R. Serum cholesterol concentration and coronary heart disease in populations with low cholesterol concentrations. BMJ. 1991;303:276–282[ISI][Medline]
  5. Yeo KR, Yeo WW, Wallis EJ, Ramsay LE. Enhanced cholesterol reduction by simvastatin in diltiazem-treated patients. Br J Clin Pharm. 1999;48:610–615[CrossRef][ISI][Medline]
  6. Davidson MH, Stein EA, Dujovne CA. The efficacy and six week tolerability of simvastatin 80 and 160mg/day. Am J Cardiol. 1997;79:38–42[ISI][Medline]
  7. He K, Iyer KR, Hayes RN, Sinz MW, Woolf TF, Hollenburg PF. Inactivation of cytochrome P450 3A4 by bergamottin, a component of grapefruit juice. Chem Res Toxicol. 1998;11:252–259[CrossRef][ISI][Medline]

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M. Bortolini
Cholesterol reduction, statins and the cytochrome P-450 system. No more recipes please
Eur. Heart J., August 2, 2001; 22(16): 1514 - 1515.
[PDF]

Home page
 Eur Heart JHome page
J.R. Cockcroft and I.B. Wilkinson
A reply
Eur. Heart J., August 2, 2001; 22(16): 1515 - 1516.
[PDF]

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