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European Heart Journal 2000 21(23):1922-1927; doi:10.1053/euhj.2000.2248
Copyright © 2000 by the European Society of Cardiology.
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Microalbuminuria is independently associated with ischaemic electrocardiographic abnormalities in a large non-diabetic population. The PREVEND (Prevention of REnal and Vascular ENdstage Disease) study

G.F.H Diercksa,f1, A.J van Bovenb, H.L Hillegea, W.M.T Janssenc, J.A Korsd, P.E de Jongc, D.E Grobbeee, H.J.G.M Crijnsb and W.H van Gilsta,b

a Department of Clinical Pharmacology, University of Groningen, Groningen, The Netherlands
b Department of Cardiology, Academic Hospital, Groningen, The Netherlands
c Department of Nephrology, Academic Hospital, Groningen, The Netherlands
d Department of Medical Informatics, Erasmus University, Rotterdam, The Netherlands
e Julius Center for Patient Oriented Research, University Medical Center, Utrecht, The Netherlands

Received April 11, 2000; accepted April 12, 2000

Abstract

Aim To assess the value of microalbuminuria as an indicator of increased cardiovascular risk in a non-diabetic population.

Methods and Results 7579 non-diabetic subjects were studied with ages ranging from 28 to 75 years selected from a population based cohort. Using computerized Minnesota coding, ischaemic electrocardiographic abnormalities were divided into three categories: infarct patterns, major ischaemia, and minor ischaemia. Urinary albumin excretion was measured as the mean of two 24-h urine collections. Cardiovascular risk indicators were defined as an age above 60 years, male sex, hypertension, hypercholesterolaemia, smoking, obesity and a positive cardiovascular family history. Microalbuminuria was associated with age, sex, blood pressure, serum cholesterol, serum glucose, body mass index and all three categories of electrocardiographic abnormalities. In a multivariate model, adjusted for established cardiovascular risk indicators, microalbuminuria was independently associated with infarct patterns (OR [95% CI] 1·61 [1·12–2·32]), major ischaemia (OR 1·43 [1·08–1·91]) and minor ischaemia (OR 1·32 [1·03–1·68]).

Conclusions The independent association between microalbuminuria and ischaemic electrocardiographic abnormalities suggests that microalbuminuria has additional value to conventional risk indicators in predicting cardiovascular disease in non-diabetics. Assessment of microalbuminuria could be an instrument to identify those at an increased risk for coronary vascular disease in an early stage.

Key Words: Microalbuminuria, electrocardiography, coronary heart disease, non-diabetic

f1 Correspondence: G. F. H. Diercks, MD, Department of Clinical Pharmacology, University of Groningen, A. Deusinglaan 1, 9713 AV Groningen, The Netherlands.

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