Skip Navigation

European Heart Journal 2001 22(10):845-848; doi:10.1053/euhj.2000.2400
Copyright © 2001 by the European Society of Cardiology.
This Article
Right arrow Abstract Freely available
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (18)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Meirhaeghe, A
Right arrow Articles by Amouyel, P
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Meirhaeghe, A
Right arrow Articles by Amouyel, P
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

The human G-protein ß3 subunit C825T polymorphism is associated with coronary artery vasoconstriction

A Meirhaeghea, C Bautersa,b, N Helbecquea, M Hamonc, E McFaddenb, J.-M Lablancheb, M Bertrandb and P Amouyela,d,f1

a Service d'Epidémiologie et de Santé Publique-INSERM U.508, Institut Pasteur de Lille, Lille Cedex, France
b Service de Cardiologie B et Hémodynamique, Hôpital Cardiologique, Lille, France
c Département de Cardiologie, Hôpital Universitaire de Caen, Côte de Nacre, France
d Centre Hospitalier et Universitaire de Lille, Lille, France

revised July 25, 2000; accepted July 26, 2000

Abstract

Aims Abnormal coronary vasomotion plays a role in the clinical expression of coronary artery disease. We hypothesized that the functional C825T polymorphism located in the ubiquitous G-protein ß3 subunit, implicated in the cellular signal transduction of many receptors, could modify artery coronary vasomotion. We assessed the potential association of the pertussis toxin-sensitive G protein ß3 subunit (GNB3) gene C825T polymorphism on coronary vasomotion in humans.

Methods and Results We examined the response of angiographically normal human coronary arteries (n=131) after intravenous injection of methylergonovine maleate, a vasoconstrictor, followed by injection of isosorbide dinitrate, a vasodilator, according to GNB3 genotypes. Coronary vasomotion was assessed with quantitative coronary angiography. Subjects bearing at least one T allele had greater susceptibility to vasoconstriction in response to methylergonovine maleate than CC subjects, whereas vasodilation in response to isosorbide dinitrate did not differ among the different genotypes.

Conclusion The C825T polymorphism of the G-protein ß3 subunit may be a genetic determinant of coronary artery vasomotion in humans.

Key Words: Genetic polymorphism, G-protein ß3 subunit, coronary artery vasomotion

f1 Correspondence: Pr. Philippe Amouyel, Service d'Epidémiologie et de Santé Publique, INSERM U.508, Institut Pasteur de Lille, 1 rue Calmette, BP 245, 59019 Lille Cedex, France.

References

  1. Cardillo C, Panza JA. Impaired endothelial regulation of vascular tone in patients with systemic arterial hypertension. Vasc Med. 1998;3:138–144[Abstract/Free Full Text]
  2. Drexler H, Hornig B. Endothelial dysfunction in human disease. J Mol Cell Cardiol. 1999;31:51–60[CrossRef][ISI][Medline]
  3. Siffert W, Rosskopf D, Siffert G. Association of a human G-protein ß3 subunit variant with hypertension. Nat Genet. 1998;18:45–48[CrossRef][ISI][Medline]
  4. Benjafield AV, Jeyasingam CL, Nyholt DR, Griffiths LR, Morris BJ. G-protein ß3 subunit gene (GNB3) variant in causation of essential hypertension. Hypertension. 1998;32:1094–1097[Abstract/Free Full Text]
  5. Hegele RA, Harris SB, Hanley AJ, Cao H, Zinman B. G protein ß3 subunit gene variant and blood pressure variation in Canadian Oji-Cree. Hypertension. 1998;32:688–692[Abstract/Free Full Text]
  6. Schunkert H, Hense HW, Doring A, Riegger GA, Siffert W. Association between a polymorphism in the G protein ß3 subunit gene and lower renin and elevated diastolic blood pressure levels. Hypertension. 1998;32:510–513[Abstract/Free Full Text]
  7. Levine MA, Modi WS, O'Brien SJ. Chromosomal localization of the genes encoding two forms of the G protein beta polypeptide, beta 1 and beta 3, in man. Genomics. 1990;8:380–386[CrossRef][ISI][Medline]
  8. Levine MA, Smallwood PM, Moen PTJ, Helman LJ, Ahn TG. Molecular cloning of beta 3 subunit, a third form of theG protein beta-subunit polypeptide. Proc Natl Acad Sci USA. 1990;87:2329–2333[Abstract/Free Full Text]
  9. Neer EJ, Schmidt CJ, Nambudripad R, Smith TF. The ancient regulatory-protein family of WD-repeat proteins. Nature. 1994;371:297–300[CrossRef][Medline]
  10. Amant C, Hamon M, Bauters C. The angiotensin II type 1 receptor gene polymorphism is associated with coronary artery vasoconstriction. J Am Coll Cardiol. 1997;29:486–490[Abstract]
  11. Brand E, Herrmann SM, Nicaud V. The 825C/T polymorphism of the G-protein subunit ß3 is not related to hypertension. Hypertension. 1999;33:1175–1178[Abstract/Free Full Text]
  12. Kato N, Sugiyama T, Morita H, Kurihara H, Yamori Y, Yazaki Y. G protein ß3 subunit variant and essential hypertension in Japanese. Hypertension. 1998;32:935–938[Abstract/Free Full Text]
  13. Siffert W, Forster P, Jockel KH. Worldwide ethnic distribution of the G protein ß3 subunit 825T allele and its association with obesity in Caucasian, Chinese, and Black African individuals. J Am Soc Nephrol. 1999;10:1921–1930[Abstract/Free Full Text]
  14. Ansari-Lari MA, Muzny DM, Lu J. A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13. Genome Res. 1996;6:314–326[Abstract/Free Full Text]
  15. Siffert W, Naber C, Walla M, Ritz E. G protein ß3 subunit 825T allele and its potential association with obesity in hypertensive individuals. J Hypertens. 1999;17:1095–1098[CrossRef][ISI][Medline]
  16. Maseri A, Davies G, Hackett D, Kaski JC. Coronary artery spasm and vasoconstriction. The case for a distinction. Circulation. 1990;81:1983–1991[Free Full Text]
  17. Docherty JR. Subtypes of functional {alpha}1- and {alpha}2-adrenoceptors. Eur J Pharmacol. 1998;361:1–15[CrossRef][ISI][Medline]
  18. Zhong H, Minneman KP. Alpha1-adrenoceptor subtypes. Eur J Pharmacol. 1999;375:261–276[CrossRef][ISI][Medline]
  19. Macrez-Lepretre N, Kalkbrenner F, Schultz G, Mironneau J. Distinct functions of Gqand G11proteins in coupling {alpha}1- adrenoreceptors to Ca2+release and Ca2+entry in rat portal vein myocytes. J Biol Chem. 1997;272:5261–5268[Abstract/Free Full Text]

Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 IOVSHome page
H. Tummala, M. Ali, P. Getty, P. M. Hocking, D. W. Burt, C. F. Inglehearn, and D. H. Lester
Mutation in the Guanine Nucleotide-Binding Protein {beta}-3 Causes Retinal Degeneration and Embryonic Mortality in Chickens
Invest. Ophthalmol. Vis. Sci., November 1, 2006; 47(11): 4714 - 4718.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
A. C. Morrison, M. S. Bray, A. R. Folsom, and E. Boerwinkle
ADD1 460W Allele Associated With Cardiovascular Disease in Hypertensive Individuals
Hypertension, June 1, 2002; 39(6): 1053 - 1057.
[Abstract] [Full Text] [PDF]

Home page
 Eur Heart JHome page
C.K. Naber, D. Baumgart, and R. Erbel
The human G protein beta3 subunit GNB3 825T polymorphism
Eur. Heart J., May 2, 2002; 23(10): 830 - 830.
[Full Text] [PDF]

Home page
 Eur Heart JHome page
H. Kuhn, F. Gietzen, and C. Leuner
'The abrupt no-flow': a no-reflow like phenomenon in hypertrophic cardiomyopathy
Eur. Heart J., January 1, 2002; 23(1): 91 - 93.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
G. Heusch, R. Erbel, and W. Siffert
Genetic determinants of coronary vasomotor tone in humans
Am J Physiol Heart Circ Physiol, October 1, 2001; 281(4): H1465 - H1468.
[Full Text] [PDF]

Home page
 Eur Heart JHome page
K. Schwartz
Polymorphism in coronary artery vasoconstriction
Eur. Heart J., May 2, 2001; 22(10): 804 - 806.
[PDF]

Home page
 Physiol. GenomicsHome page
T. Rankinen, T. Rice, A. S. Leon, J. S. Skinner, J. H. Wilmore, D. C. Rao, and C. Bouchard
G protein {beta}3 polymorphism and hemodynamic and body composition phenotypes in the HERITAGE Family Study
Physiol Genomics, February 28, 2002; 8(2): 151 - 157.
[Abstract] [Full Text] [PDF]

This Article
Right arrow Abstract Freely available
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (18)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Meirhaeghe, A
Right arrow Articles by Amouyel, P
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Meirhaeghe, A
Right arrow Articles by Amouyel, P
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?