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European Heart Journal 2001 22(11):898-902; doi:10.1053/euhj.2000.2323
Copyright © 2001 by the European Society of Cardiology.
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Clinical Trials

The general concepts of an equivalence trial, applied to ASSENT-2, a large-scale mortality study comparing two fibrinolytic agents in acute myocardial infarction

E Lesaffrea,f1, E Bluhmkib, F Wang-Clowc, S Beriolib, T Danaysb, N.L Foxc and F Van de Werfd

a Biostatistical Centre, University of Leuven, Belgium
b Boehringer Ingelheim Pharma KG, Ingelheim, Germany
c Genentech Inc. San Francisco, USA
d Department of Cardiology, University of Leuven, Belgium

Key Words: Alteplase, equivalence, mortality, myocardial infarction, non-inferiority, tenecteplase

f1 Correspondence: Emmanuel Lesaffre, Biostatistical Centre, U.Z. St. Rafael, Kapucijnenvoer 35, 3000 Leuven, Belgium.

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This Article
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