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European Heart Journal 2001 22(15):1245-1247; doi:10.1053/euhj.2001.2597
Copyright © 2001 by the European Society of Cardiology.
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Editorials

The radioactive stent — any chance of a resurrection?

A. Arab, C. Bode and C. Hehrlein

Department of Cardiology, University of Freiburg, Freiburg, Germany

Abstract

No Abstract

References

  1. Hehrlein C, Fischell TA. History of the radioisotope stent. Vasc Radiotherapy Mon. 1999;1:66–69
  2. Hehrlein C, Zimmermann M, Metz J. Radioactive coronary stent implantation inhibits neointimal proliferation in nonatherosclerotic rabbits (Abstr). Circulation. 1993;88:II-651
  3. Fischell TA, Kharma BK, Fischell DR. Low-dose, beta-particle emission from ‘stent’ wire results in complete, localized inhibition of smooth muscle cell proliferation. Circulation. 1994;90:2956–2963[Abstract/Free Full Text]
  4. Hehrlein C, Gollan C, Dönges K. Low-dose radioactive endovascular stents prevent smooth muscle cell proliferation and neointimal hyperplasia in rabbits. Circulation. 1995;92:1570–1575[Abstract/Free Full Text]
  5. Hehrlein C, Stintz M, Kinscherf R. Pure beta-particle-emitting stents inhibit neointima formation in rabbits. Circulation. 1996;93:641–645[Abstract/Free Full Text]
  6. Fischell TA, Hehrlein C. The radioisotope stent for the prevention of restenosis. Herz. 1998;23:373–379[ISI][Medline]
  7. Hehrlein C. Radioactive stents: European experience. Waksman R. Vascular Brachytherapy. Armonk: Futura; 1999. p. 333–342
  8. Fischell TA, Hehrlein C, Fischell RE. The impact of stent design and delivery upon the long term efficacy of radioisotope stents. J Invas Cardiol. 2000;12:162–167[ISI][Medline]
  9. Kay IP, Wardeh AJ, Kozuma K. The pattern of restenosis and vascualr remodelling after cold-end radioactive stent implantation. Eur Heart J. 2001;22:1311–1317[Abstract/Free Full Text]
  10. Liu MW, Roubin GS, King SB III. Restenosis after coronary angioplasty. Potential biologic determinants and role of intimal hyperplasia. Circulation. 1989;79:1374–1387[Abstract/Free Full Text]
  11. Schwartz RS, Edwards WD, Bailey KR. Differential neointimal response to coronary artery injury in pigs and dogs. Implications for restenosis models. Arterioscler Thromb Vasc Biol. 1994;14:395–400[Abstract/Free Full Text]
  12. Hehrlein C, Kollum M, Arab A. Increased apoptotic cell death in the neointima after stent-based vascular irradiation. Role of radiation-induced apoptosis for restenosis reduction. J Intervent Cardiol. 1999;12:299–304
  13. Fischell TA, Hehrlein C, Lauer MA. Initial results with a gamma-emitting (PD-103) radioisotope stent in a rabbit iliac overstretch injury model (Abstr). Circulation. 2000;102:II-669
  14. Lauer MA, Devries JJ, Haller SD. Initial Results with a 32P radioactive self-expanding nitinol stent (Abstr). Circulation. 2000;102:II-424
  15. Hehrlein C, Kovacs A, Wolf GK. A novel balloon angioplasty catheter impregnated with beta-particle emitting radioisotopes for vascular brachytherapy to prevent restenosis. First in vivo results. Eur Heart J. 2000;21:2056–2062[Abstract/Free Full Text]
  16. Albiero R, Adamian M, Kobayashi N. Short-and intermediate-term results of 32P radioactive ß-emitting stent implantation in patients with coronary artery disease. Circulation. 2000;101:18–26[Abstract/Free Full Text]
  17. Albiero R, Nishida T, Adamian M. Edge restenosis after implantation of high activity 32P radioactive ß-emitting stents. Circulation. 2000;101:2454–2460[Abstract/Free Full Text]
  18. Rogers C, Groothuis A, Steijskal E. Paclitaxel release from inert polymer material-coated stent curtails coronary in-stent restenosis in pigs (Abstr). Circulation. 2000;102:II-566

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[Abstract] [Full Text] [PDF]


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